| Literature DB >> 19734093 |
Moritz Treeck1, Marco Tamborrini, Claudia A Daubenberger, Tim W Gilberger, Till S Voss.
Abstract
Apical membrane antigen 1 (AMA1) plays an essential role in host cell invasion by apicomplexan parasites. A recent study by Collins et al. investigated the mode of action of an anti-AMA1 invasion-inhibitory antibody. They demonstrated the interference of this antibody with invasion complex formation, which was dependent in turn on a single conserved tyrosine residue in AMA1. Their findings reveal important new insights into parasite biology and are highly relevant for rational vaccine design.Entities:
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Year: 2009 PMID： 19734093 DOI： 10.1016/j.pt.2009.07.008
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922