Literature DB >> 19734054

GPR30/GPER1: searching for a role in estrogen physiology.

Björn Olde1, L M Fredrik Leeb-Lundberg.   

Abstract

Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

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Year:  2009        PMID： 19734054     DOI： 10.1016/j.tem.2009.04.006

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  75 in total

Review 1.  Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.

Authors:  M R Meyer; D J Clegg; E R Prossnitz; M Barton
Journal:  Acta Physiol (Oxf)       Date:  2011-02-01       Impact factor: 6.311

Review 2.  Interplay of estrogen receptors and FOXA factors in the liver cancer.

Authors:  Yongbing Zhao; Zhaoyu Li
Journal:  Mol Cell Endocrinol       Date:  2015-02-04       Impact factor: 4.102

Review 3.  Differential Roles of Hypothalamic AVPV and Arcuate Kisspeptin Neurons in Estradiol Feedback Regulation of Female Reproduction.

Authors:  Luhong Wang; Suzanne M Moenter
Journal:  Neuroendocrinology       Date:  2019-08-30       Impact factor: 4.914

4.  Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents.

Authors:  Tapan K Nayak; Megan K Dennis; Chinnasamy Ramesh; Ritwik Burai; Robert W Atcher; Larry A Sklar; Jeffrey P Norenberg; Helen J Hathaway; Jeffrey B Arterburn; Eric R Prossnitz
Journal:  ACS Chem Biol       Date:  2010-07-16       Impact factor: 5.100

5.  GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding.

Authors:  Tapan K Nayak; Chinnasamy Ramesh; Helen J Hathaway; Jeffrey P Norenberg; Jeffrey B Arterburn; Eric R Prossnitz
Journal:  Mol Cancer Res       Date:  2014-07-16       Impact factor: 5.852

Review 6.  The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.

Authors:  Milad Hasanpour; Alireza Nourazarian; Mohammad Hossein Geranmayeh; Masoud Nikanfar; Fatemeh Khaki-Khatibi; Reza Rahbarghazi
Journal:  Neuromolecular Med       Date:  2018-05-04       Impact factor: 3.843

Review 7.  Emerging roles of GPER in diabetes and atherosclerosis.

Authors:  Matthias Barton; Eric R Prossnitz
Journal:  Trends Endocrinol Metab       Date:  2015-03-09       Impact factor: 12.015

8.  GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol.

Authors:  Melissa A Yates; Yuexin Li; Peter J Chlebeck; Halina Offner
Journal:  BMC Immunol       Date:  2010-04-19       Impact factor: 3.615

Review 9.  G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis.

Authors:  Haifei Shi; Shiva Priya Dharshan Senthil Kumar; Xian Liu
Journal:  Prog Mol Biol Transl Sci       Date:  2013       Impact factor: 3.622

10.  G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

Authors:  Patricia M Lenhart; Stefan Broselid; Cordelia J Barrick; L M Fredrik Leeb-Lundberg; Kathleen M Caron
Journal:  J Mol Endocrinol       Date:  2013-07-03       Impact factor: 5.098
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