Literature DB >> 1973362

Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.

U Weidner1, S Peter, T Strohmeyer, R Hussnätter, R Ackermann, H Sies.   

Abstract

Expression of the oncogenes, epidermal growth factor (EGF) receptor, HER2/neu, c-myc, and c-fos, in renal cell carcinoma and corresponding nonneoplastic kidney tissue of 30 patients has been analyzed by Northern blot analysis. In renal cell carcinoma an inverse relationship of EGF receptor and HER2/neu gene expression was detected, with high expression of the EGF receptor gene in 22 of 30 (73%) cases and low expression of the HER2/neu gene in 28 of 30 (93%) cases. Furthermore, altered expression of the oncogenes c-myc and c-fos was detected in renal cell carcinoma, which appears to be related to the tumor grade of malignancy. Additional Southern blot analysis of six renal cell carcinomas gave no indication of chromosomal rearrangement events or gene amplification.

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Year:  1990        PMID： 1973362

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  21 in total

1.  The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity.

Authors:  D Mukhopadhyay; B Knebelmann; H T Cohen; S Ananth; V P Sukhatme
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Monoclonal antibody (MAB) in patients with advanced cancer.

Authors:  Hyung L Kim; Allan J Pantuck; Nazy Zomorodian; Arie S Belldegrun
Journal:  Curr Urol Rep       Date:  2003-02       Impact factor: 3.092

3.  Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization.

Authors:  H Bissig; J Richter; R Desper; V Meier; P Schraml; A A Schäffer; G Sauter; M J Mihatsch; H Moch
Journal:  Am J Pathol       Date:  1999-07       Impact factor: 4.307

Review 4.  Renal cell carcinoma.

Authors:  Paul Cairns
Journal:  Cancer Biomark       Date:  2010       Impact factor: 4.388

5.  Induction of renal adenocarcinoma by a nonmutated erbB oncogene.

Authors:  C A Taglienti-Sian; B Banner; R J Davis; H L Robinson
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

6.  Epidermal growth factor receptor gene expression and binding capacity in renal cell carcinoma, in relation to tumor stage, grade and DNA ploidy.

Authors:  B Ljungberg; M Gåfvels; J E Damber
Journal:  Urol Res       Date:  1994

Review 7.  The value of molecular genetic analysis in the diagnosis and prognosis of renal cell tumours.

Authors:  G Kovacs
Journal:  World J Urol       Date:  1994       Impact factor: 4.226

8.  Genetic alterations of HER genes in chromophobe renal cell carcinoma.

Authors:  Wen Hui Weng; Ying Tzu Chen; Kai Jie Yu; Ying Hsu Chang; Cheng Keng Chuang; See Tong Pang
Journal:  Oncol Lett       Date:  2016-02-08       Impact factor: 2.967

9.  Expression of c-erbB-2 protein and epidermal growth factor receptor in normal tissues of the female genital tract and in the placenta.

Authors:  D P Wang; S Fujii; I Konishi; Y Nanbu; T Iwai; H Nonogaki; T Mori
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

10.  c-fos oncogene underexpression in salivary gland tumors as measured by in situ hybridization.

Authors:  C Birek; E Lui; I Dardick
Journal:  Am J Pathol       Date:  1993-03       Impact factor: 4.307
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