OBJECTIVE: Our aim was to examine perinatal outcomes in women who are infected with human immunodeficiency virus (HIV) and who receive highly active antiretroviral therapy compared with the general population. STUDY DESIGN: In this retrospective cohort study, we compared 151 HIV-positive and 302 HIV-negative women. We defined highly active antiretroviral therapy as concomitant use of at least 3 antiretroviral drugs. We calculated frequencies and odds ratios for adverse pregnancy outcomes. RESULTS: Compared with control subjects, smoking (odds ratio, 4.62; 95% confidence interval [CI], 2.58-8.27), drug abuse (odds ratio, 5.48; 95% CI, 2.21-13.59), and spontaneous preterm birth (adjusted odds ratio, 2.27; 95% CI, 1.22-4.25) were more common among HIV-positive women. HIV-positive women were more likely to deliver a small-for-gestational-age infant, but this was due to higher tobacco and cocaine use. Neonatal outcomes were otherwise similar. CONCLUSION: HIV-positive women are at increased risk for preterm birth and lower birthweight infants; therefore, antenatal surveillance should include fetal growth assessment. Highly active antiretroviral therapy use does not increase maternal complications.
OBJECTIVE: Our aim was to examine perinatal outcomes in women who are infected with human immunodeficiency virus (HIV) and who receive highly active antiretroviral therapy compared with the general population. STUDY DESIGN: In this retrospective cohort study, we compared 151 HIV-positive and 302 HIV-negative women. We defined highly active antiretroviral therapy as concomitant use of at least 3 antiretroviral drugs. We calculated frequencies and odds ratios for adverse pregnancy outcomes. RESULTS: Compared with control subjects, smoking (odds ratio, 4.62; 95% confidence interval [CI], 2.58-8.27), drug abuse (odds ratio, 5.48; 95% CI, 2.21-13.59), and spontaneous preterm birth (adjusted odds ratio, 2.27; 95% CI, 1.22-4.25) were more common among HIV-positive women. HIV-positive women were more likely to deliver a small-for-gestational-age infant, but this was due to higher tobacco and cocaine use. Neonatal outcomes were otherwise similar. CONCLUSION:HIV-positive women are at increased risk for preterm birth and lower birthweight infants; therefore, antenatal surveillance should include fetal growth assessment. Highly active antiretroviral therapy use does not increase maternal complications.
Authors: W Todd Cade; Gautam K Singh; Mark R Holland; Dominic N Reeds; E Turner Overton; Nancy Cibulka; Karen Bahow; Rachel Presti; Andrea Stephens; Alison G Cahill Journal: Clin Nutr ESPEN Date: 2015-08-01
Authors: Jennifer Jao; Keith M Sigel; Katherine T Chen; Gabriela Rodriguez-Caprio; Roberto Posada; Gail Shust; Juan Wisnivesky; Elaine J Abrams; Rhoda S Sperling Journal: AIDS Date: 2012-04-24 Impact factor: 4.177
Authors: Kathleen M Powis; Thomas F McElrath; Michael D Hughes; Anthony Ogwu; Sajini Souda; Saul A Datwyler; Erik von Widenfelt; Sikhulile Moyo; Marisa Nádas; Joseph Makhema; Esther Machakaire; Shahin Lockman; Max Essex; Roger L Shapiro Journal: J Acquir Immune Defic Syndr Date: 2013-04-15 Impact factor: 3.731
Authors: Marie C D Stoner; Bellington Vwalika; Marcela C Smid; Shalin George; Benjamin H Chi; Elizabeth M Stringer; Jeffrey S A Stringer Journal: Int J Gynaecol Obstet Date: 2016-05-25 Impact factor: 3.561
Authors: Ryan Ng; Erin M Macdonald; Mark H Yudin; Ahmed M Bayoumi; Mona R Loutfy; Janet Raboud; Khatundi-Irene Masinde; Wangari E Tharao; Jason Brophy; Richard H Glazier; Tony Antoniou Journal: CMAJ Open Date: 2015-10-19
Authors: M López; M Palacio; A Goncé; S Hernàndez; F J Barranco; L García; M Loncà; J O Coll; E Gratacós; F Figueras Journal: Eur J Clin Microbiol Infect Dis Date: 2014-08-09 Impact factor: 3.267
Authors: Amina P Alio; Alfred K Mbah; Krupa Shah; Euna M August; Sharon Dejoy; Korede Adegoke; Phillip J Marty; Hamisu M Salihu; Muktar H Aliyu Journal: Am J Mens Health Date: 2013-08-02