Literature DB >> 19733004

Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array.

Yukiyasu Okamura1, Shuji Nomoto, Mitsuro Kanda, Qiyong Li, Yoko Nishikawa, Hiroyuki Sugimoto, Naohito Kanazumi, Shin Takeda, Akimasa Nakao.   

Abstract

Hepatocellular carcinoma (HCC) is one of the world's top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9%) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P<0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19733004     DOI： 10.1016/j.canlet.2009.08.013

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  26 in total

1.  Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma.

Authors:  Yong Gu Cho; Xiaofei Chang; Il-Seok Park; Keishi Yamashita; Chunbo Shao; Patrick K Ha; Sara I Pai; David Sidransky; Myoung Sook Kim
Journal:  Int J Oncol       Date:  2011-05-23       Impact factor: 5.650

2.  Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis.

Authors:  Daisuke Kobayashi; Shuji Nomoto; Yasuhiro Kodera; Michitaka Fujiwara; Masahiko Koike; Goro Nakayama; Norifumi Ohashi; Akimasa Nakao
Journal:  World J Surg       Date:  2012-02       Impact factor: 3.352

3.  Molecular alterations in the carcinogenesis and progression of hepatocellular carcinoma: Tumor factors and background liver factors.

Authors:  Yoshikuni Inokawa; Kenichi Inaoka; Fuminori Sonohara; Masamichi Hayashi; Mitsuro Kanda; Shuji Nomoto
Journal:  Oncol Lett       Date:  2016-09-15       Impact factor: 2.967

Review 4.  DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma.

Authors:  Sumadi Lukman Anwar; Ulrich Lehmann
Journal:  World J Gastroenterol       Date:  2014-06-28       Impact factor: 5.742

5.  A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion.

Authors:  Jun-Hua Zhao; Jing-Xu Sun; Yong-Xi Song; Xiao-Wan Chen; Yu-Chong Yang; Bin Ma; Jun Wang; Peng Gao; Zhen-Ning Wang
Journal:  J Cancer Res Clin Oncol       Date:  2015-11-04       Impact factor: 4.553

6.  Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.

Authors:  Shu-Chen Liu; Ngan-Ming Tsang; Wen-Che Chiang; Kai-Ping Chang; Chuen Hsueh; Ying Liang; Jyh-Lyh Juang; Kai-Ping N Chow; Yu-Sun Chang
Journal:  J Clin Invest       Date:  2013-11-25       Impact factor: 14.808

7.  Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules.

Authors:  Qin Luo; Yurong Zhang; Ning Wang; Guangzhi Jin; Haojie Jin; Dishui Gu; Xuemei Tao; Xisong Huo; Tianxiang Ge; Wenming Cong; Cun Wang; Wenxin Qin
Journal:  Oncotarget       Date:  2015-03-30

Review 8.  New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology.

Authors:  Maria D Giraldez; David Carneros; Christoph Garbers; Stefan Rose-John; Matilde Bustos
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2021-07-01       Impact factor: 46.802

9.  Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.

Authors:  Winnie S Liang; David W Craig; John Carpten; Mitesh J Borad; Michael J Demeure; Glen J Weiss; Tyler Izatt; Shripad Sinari; Alexis Christoforides; Jessica Aldrich; Ahmet Kurdoglu; Michael Barrett; Lori Phillips; Hollie Benson; Waibhav Tembe; Esteban Braggio; Jeffrey A Kiefer; Christophe Legendre; Richard Posner; Galen H Hostetter; Angela Baker; Jan B Egan; Haiyong Han; Douglas Lake; Edward C Stites; Ramesh K Ramanathan; Rafael Fonseca; A Keith Stewart; Daniel Von Hoff
Journal:  PLoS One       Date:  2012-10-10       Impact factor: 3.240

10.  Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker.

Authors:  Saleh M Rachidi; Tingting Qin; Shaoli Sun; W Jim Zheng; Zihai Li
Journal:  PLoS One       Date:  2013-03-25       Impact factor: 3.240
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