BACKGROUND: Available data regarding posttraumatic stress disorder (PTSD) in bipolar disorder (BD) are scarce and usually from a limited sample size. The present report was carried out using the Brazilian Research Consortium for Bipolar Disorders and aimed to examine whether patients with BD and comorbid PTSD are at an increased risk for worse clinical outcomes. METHODS: A consecutive sample of bipolar I outpatients from two teaching hospitals in Brazil was recruited. Patients were assessed using the Structured Clinical Interview for DSM-IV, Young Mania Rating Scale, 17-item Hamilton Rating Scale for Depression, and quality of life instrument WHOQOL-BREF. Participants were divided into three groups: a. bipolar patients with PTSD, b. bipolar patients exposed to trauma without PTSD, and c. bipolar patients with no trauma exposure. RESULTS: Of the 405 patients who consented to participate, 87.7% completed the survey. All three groups were similar in terms of demographic parameters. The group with comorbid PTSD reported worse quality of life, more rapid cycling, higher rates of suicide attempts, and a lower likelihood of staying recovered. LIMITATIONS: The cross-sectional design excludes the opportunity to examine causal relationships among trauma, PTSD, and BD. CONCLUSIONS: The findings indicate that PTSD causes bipolar patients to have a worse outcome, as assessed by their lower likelihood to recover, elevated proportion of rapid cycling periods, increased risk of suicide attempts, and worse quality of life. Copyright 2009 Elsevier B.V. All rights reserved.
BACKGROUND: Available data regarding posttraumatic stress disorder (PTSD) in bipolar disorder (BD) are scarce and usually from a limited sample size. The present report was carried out using the Brazilian Research Consortium for Bipolar Disorders and aimed to examine whether patients with BD and comorbid PTSD are at an increased risk for worse clinical outcomes. METHODS: A consecutive sample of bipolar I outpatients from two teaching hospitals in Brazil was recruited. Patients were assessed using the Structured Clinical Interview for DSM-IV, Young Mania Rating Scale, 17-item Hamilton Rating Scale for Depression, and quality of life instrument WHOQOL-BREF. Participants were divided into three groups: a. bipolarpatients with PTSD, b. bipolarpatients exposed to trauma without PTSD, and c. bipolarpatients with no trauma exposure. RESULTS: Of the 405 patients who consented to participate, 87.7% completed the survey. All three groups were similar in terms of demographic parameters. The group with comorbid PTSD reported worse quality of life, more rapid cycling, higher rates of suicide attempts, and a lower likelihood of staying recovered. LIMITATIONS: The cross-sectional design excludes the opportunity to examine causal relationships among trauma, PTSD, and BD. CONCLUSIONS: The findings indicate that PTSD causes bipolarpatients to have a worse outcome, as assessed by their lower likelihood to recover, elevated proportion of rapid cycling periods, increased risk of suicide attempts, and worse quality of life. Copyright 2009 Elsevier B.V. All rights reserved.
Authors: Ellen B Dennehy; Lauren B Marangell; Michael H Allen; Cheryl Chessick; Stephen R Wisniewski; Michael E Thase Journal: J Affect Disord Date: 2011-05-20 Impact factor: 4.839
Authors: Ana Moreno-Alcázar; Joaquim Radua; Ramon Landín-Romero; Laura Blanco; Mercè Madre; Maria Reinares; Mercè Comes; Esther Jiménez; Jose Manuel Crespo; Eduard Vieta; Victor Pérez; Patricia Novo; Marta Doñate; Romina Cortizo; Alicia Valiente-Gómez; Walter Lupo; Peter J McKenna; Edith Pomarol-Clotet; Benedikt L Amann Journal: Trials Date: 2017-04-04 Impact factor: 2.279
Authors: Peihao Fan; Xiaojiang Guo; Xiguang Qi; Mallika Matharu; Ravi Patel; Dara Sakolsky; Levent Kirisci; Jonathan C Silverstein; Lirong Wang Journal: Brain Sci Date: 2020-10-27