Literature DB >> 1973276

L-[3H]glutamate labels the metabotropic excitatory amino acid receptor in rodent brain.

J H Cha1, R L Makowiec, J B Penney, A B Young.   

Abstract

A quantitative autoradiographic assay for a novel L-[3H]glutamate binding site in rodent brain has been developed. Binding to this site was distinguished by its high affinity for quisqualate (QA), ibotenate, glutamate and trans-1-amino-cyclopentyl-1,3-dicarboxylic acid (trans-ACPD), but low affinity for [RS]-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA). 'AMPA-insensitive, QA-sensitive [3H]glutamate binding' (AiQsGB) had a heterogeneous distribution in rat brain with high levels observed in molecular layer of cerebellum, striatum, and lateral septum. AiQsGB was reduced in molecular layer of cerebellum in mice lacking Purkinje cells. AiQsGB appears to represent binding to the 'metabotropic' neuronal excitatory amino acid receptor linked to phosphoinositide metabolism.

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Year:  1990        PMID： 1973276     DOI： 10.1016/0304-3940(90)90498-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

1.  From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease.

Authors:  S W Davies; M Turmaine; B A Cozens; A S Raza; A Mahal; L Mangiarini; G P Bates
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

Review 2.  Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease.

Authors:  J H Cha; A S Frey; S A Alsdorf; J A Kerner; C M Kosinski; L Mangiarini; J B Penney; S W Davies; G P Bates; A B Young
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

3.  Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene.

Authors:  J H Cha; C M Kosinski; J A Kerner; S A Alsdorf; L Mangiarini; S W Davies; J B Penney; G P Bates; A B Young
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

4.  Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation.

Authors:  E A Hackler; N E Byun; C K Jones; J M Williams; R Baheza; S Sengupta; M D Grier; M Avison; P J Conn; J C Gore
Journal:  Neuroscience       Date:  2010-03-27       Impact factor: 3.590

5.  Activation of a metabotropic excitatory amino acid receptor potentiates spike-driven calcium increases in neurons of the dorsolateral septum.

Authors:  F Zheng; J P Gallagher; J A Connor
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

6.  Anion transport blockers inhibit DL-2-amino-4-phosphonobutyrate responses induced by quisqualate in the rat cerebral cortex.

Authors:  J P Turner
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

7.  Non-NMDA excitatory amino acid receptors in a subcellular fraction enriched in cerebellar glomeruli.

Authors:  F Viennot; J de Barry; G Gombos
Journal:  Neurochem Res       Date:  1991-04       Impact factor: 3.996

8.  β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.

Authors:  Xianchong Zhou; Wilfredo Escala; Spyridon Papapetropoulos; R Grace Zhai
Journal:  Toxins (Basel)       Date:  2010-11-03       Impact factor: 4.546
  8 in total

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