Literature DB >> 19732715

Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.

Matthew P Strout1, David G Schatz.   

Abstract

Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enzyme activation-induced deaminase (AID) in the generation of mutations associated with disease progression and drug resistance in chronic myeloid leukemia.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19732715     DOI： 10.1016/j.ccr.2009.08.012

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  6 in total

1.  Targeted blockage of signal transducer and activator of transcription 5 signaling pathway with decoy oligodeoxynucleotides suppresses leukemic K562 cell growth.

Authors:  Xiaozhong Wang; Jianming Zeng; Mei Shi; Shiqiao Zhao; Weijun Bai; Weixi Cao; Zhiguang Tu; Zonggan Huang; Wenli Feng
Journal:  DNA Cell Biol       Date:  2010-11-22       Impact factor: 3.311

2.  Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway.

Authors:  Yan-jun Zhang; Cheng-rong Lu; Yan Cao; Yuan Luo; Rong-feng Bao; Shu Yan; Mei Xue; Feng Zhu; Zhe Wang; Lian-ning Duan
Journal:  Acta Pharmacol Sin       Date:  2012-03-05       Impact factor: 6.150

3.  Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B.

Authors:  Justin J King; Faezeh Borzooee; Junbum Im; Mahdi Asgharpour; Atefeh Ghorbani; Cody P Diamond; Heather Fifield; Lesley Berghuis; Mani Larijani
Journal:  ACS Pharmacol Transl Sci       Date:  2021-07-19

Review 4.  Regulation of Aicda expression and AID activity.

Authors:  Hong Zan; Paolo Casali
Journal:  Autoimmunity       Date:  2013-01-17       Impact factor: 2.815

5.  Concomitant AID Expression and BCL7A Loss Associates With Accelerated Phase Progression and Imatinib Resistance in Chronic Myeloid Leukemia.

Authors:  Nae Yu; Saeam Shin; Jong Rak Choi; Yoonjung Kim; Kyung A Lee
Journal:  Ann Lab Med       Date:  2017-03       Impact factor: 3.464

6.  Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis.

Authors:  C Calderón-Cabrera; I Montero; R M Morales; J Sánchez; E Carrillo; T Caballero-Velázquez; C Prats; R Bernal; J M De Blas; J A Pérez-Simón
Journal:  Leuk Res Rep       Date:  2013-09-21
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.