Fetal hypoxia insults and patterns of brain injury: insights from animal models.

The outcome of perinatal hypoxiaischemia is highly variable, with only a very broad relationship to the 'severity' of oxygen debt as shown by peripheral base deficit and the risk of damage. The present article examines the pathophysiology of asphyxial injury. We dissect the multiple factors that modify the risk of injury, including the depth ('severity'), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation.