Literature DB >> 1973140

A physical map of the human PI and AACT genes.

L Sefton1, G Kelsey, P Kearney, S Povey, J Wolfe.   

Abstract

We have used probes from the human genes PI, PIL, and AACT (alpha 1-antitrypsin, alpha 1-antitrypsin-related sequence, and alpha 1-antichymotrypsin) to make a pulsed-field map of the surrounding region of 14q31-32. We have discovered that the PI-PIL gene cluster is only 220 kb away from the AACT gene and that it is orientated in the opposite direction. The comparatively short distance between the genes comes as a surprise given previous estimates of the level of genetic recombination between them.

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Year:  1990        PMID： 1973140     DOI： 10.1016/0888-7543(90)90172-q

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  3 in total

1.  Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1.

Authors:  P Rollini; R E Fournier
Journal:  Mamm Genome       Date:  1997-12       Impact factor: 2.957

2.  Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.

Authors:  G D Billingsley; M A Walter; G L Hammond; D W Cox
Journal:  Am J Hum Genet       Date:  1993-02       Impact factor: 11.025

3.  Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency.

Authors:  B C Byth; G D Billingsley; D W Cox
Journal:  Am J Hum Genet       Date:  1994-07       Impact factor: 11.025
  3 in total

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