Literature DB >> 1973112

Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain.

M Gobbi1, E Frittoli, T Mennini.   

Abstract

The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K(+)-evoked [3H]noradrenaline and [3H]serotonin release from superfused synaptosomes obtained from rat cerebral cortex. PmP had no effects per se, but antagonized the effect of noradrenaline, producing a parallel shift to the right of the noradrenaline inhibition curves. From these data pA2 (apparent affinity) values of 6.8 and 7.3 were calculated for PmP on presynaptic alpha 2-adrenoceptors located on noradrenergic and serotonergic nerve terminals, respectively.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1973112     DOI： 10.1016/0014-2999(90)90608-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Increased levels of extracellular noradrenaline in the frontal cortex of rats exposed to naturalistic environmental stimuli: modulation by acute systemic administration of diazepam or buspirone.

Authors:  J W Dalley; K Mason; S C Stanford
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530

2.  Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.

Authors:  P M Grasby; K J Friston; C Bench; P J Cowen; C D Frith; P F Liddle; R S Frackowiak; R J Dolan
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat.

Authors:  P M Grasby; T Sharp; T Allen; P A Kelly; D G Grahame-Smith
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

4.  Increase of noradrenaline release in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine1A receptor activation.

Authors:  M Suzuki; T Matsuda; S Asano; P Somboonthum; K Takuma; A Baba
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739

5.  The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype.

Authors:  M Gobbi; E Frittoli; T Mennini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-10       Impact factor: 3.000
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.