Literature DB >> 1973034

Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells.

M H Fukami1, J Haavik, T Flatmark.   

Abstract

Incubation of bovine chromaffin cells with L-[14C]phenylalanine resulted in label accumulation in catecholamines at about 30% of the rate seen with L-tyrosine as precursor. Studies with purified tyrosine hydroxylase (EC 1.14.16.2) showed that the enzyme catalysed the hydroxylation of L-phenylalanine first to L-p-tyrosine and then to 3,4-dihydroxyphenylalanine (DOPA). No evidence for a significant involvement of an L-m-tyrosine intermediate in DOPA formation was found.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1973034      PMCID： PMC1131466          DOI： 10.1042/bj2680525

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  HYDROXYLATION OF PHENYLALANINE BY PURIFIED PREPARATIONS OF ADRENAL AND BRAIN TYROSINE HYDROXYLASE.

Authors:  M IKEDA; M LEVITT; S UDENFRIEND
Journal:  Biochem Biophys Res Commun       Date:  1965-02-17       Impact factor: 3.575

2.  Formation of meta-tyrosine form L-phenylalanine by beef adrenal medulla. A new biosynthetic route to catecholamines.

Authors:  J H Tong; A D'Iorio; N L Benoiton
Journal:  Biochem Biophys Res Commun       Date:  1971-07-02       Impact factor: 3.575

3.  The formation of 3,4-dihydroxy-L-phenylalanine from L-meta-tyrosine by rat liver and beef adrenal medulla.

Authors:  J H Tong; A D'Iorio; N L Benoiton
Journal:  Biochem Biophys Res Commun       Date:  1971-05-21       Impact factor: 3.575

4.  Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

Authors:  J W Haycock; J A Meligeni; W F Bennett; J C Waymire
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157

5.  Rapid and sensitive assay of tyrosine 3-monooxygenase activity by high-performance liquid chromatography using the native fluorescence of DOPA.

Authors:  J Haavik; T Flatmark
Journal:  J Chromatogr       Date:  1980-10-24

6.  Formation of catecholamines from phenylalanine in brain--effects of chlorpromazine and catron.

Authors:  S P Bagchi; E P Zarycki
Journal:  Biochem Pharmacol       Date:  1973-06-01       Impact factor: 5.858

7.  Selection for neuroblastoma cells that synthesize certain transmitters.

Authors:  X O Breakefield; M W Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

8.  Phenylalanine as substrate and inhibitor of tyrosine hydroxylase.

Authors:  M Ikeda; M Levitt; S Udenfriend
Journal:  Arch Biochem Biophys       Date:  1967-05       Impact factor: 4.013

9.  Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid.

Authors:  A A Badawy; D L Williams
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857

10.  The non-enzymic hydroxylation of phenylalanine to tyrosine by 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine.

Authors:  L I Woolf; A Jakubovic; E Chan-Henry
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857
View more
  6 in total

1.  The effect of phenylalanine on DOPA synthesis in PC12 cells.

Authors:  F R DePietro; J D Fernstrom
Journal:  Neurochem Res       Date:  1998-07       Impact factor: 3.996

2.  Characterization of a novel pterin intermediate formed in the catalytic cycle of tyrosine hydroxylase.

Authors:  B Almås; J Haavik; T Flatmark
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

3.  Enzymic sulphation of dopa and tyrosine isomers by HepG2 human hepatoma cells: stereoselectivity and stimulation by Mn2+.

Authors:  M Suiko; Y Sakakibara; H Nakajima; H Sakaida; M C Liu
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

4.  Metabolic phenotypes of phenylketonuria. Kinetic and molecular evaluation of the Blaskovics protein loading test.

Authors:  U Langenbeck; P Burgard; U Wendel; M Lindner; J Zschocke
Journal:  J Inherit Metab Dis       Date:  2009-07-16       Impact factor: 4.982

5.  Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40.

Authors:  K K Andersson; C Vassort; B A Brennan; L Que; J Haavik; T Flatmark; F Gros; J Thibault
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

6.  Tyrosine hydroxylase activity and extrinsic fluorescence changes produced by polyanions.

Authors:  L G Gahn; R Roskoski
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.