Literature DB >> 19729474

Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.

Stephen L Nishimura1.   

Abstract

A subset of integrins function as cell surface receptors for the profibrotic cytokine transforming growth factor-beta (TGF-beta). TGF-beta is expressed in an inactive or latent form, and activation of TGF-beta is a major mechanism that regulates TGF-beta function. Indeed, important TGF-beta activation mechanisms involve several of the TGF-beta binding integrins. Knockout mice suggest essential roles for integrin-mediated TGF-beta activation in vessel and craniofacial morphogenesis during development and in immune homeostasis and the fibrotic wound healing response in the adult. Amplification of integrin-mediated TGF-beta activation in fibrotic disorders and data from preclinical models suggest that integrins may therefore represent novel targets for antifibrotic therapies.

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Year:  2009        PMID： 19729474      PMCID： PMC2751532          DOI： 10.2353/ajpath.2009.090393

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  105 in total

1.  Characterization of integrin beta6 and thrombospondin-1 double-null mice.

Authors:  Anna Ludlow; Karen O Yee; Ruth Lipman; R Bronson; P Weinreb; Xiaozhu Huang; D Sheppard; J Lawler
Journal:  J Cell Mol Med       Date:  2005 Apr-Jun       Impact factor: 5.310

2.  Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts.

Authors:  Yoshihde Asano; Hironobu Ihn; Kenichi Yamane; Masatoshi Jinnin; Yoshihiro Mimura; Kunihiko Tamaki
Journal:  Arthritis Rheum       Date:  2005-09

3.  TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis.

Authors:  Philippe Bonniaud; Peter J Margetts; Kjetil Ask; Kathy Flanders; Jack Gauldie; Martin Kolb
Journal:  J Immunol       Date:  2005-10-15       Impact factor: 5.422

Review 4.  Specificity and versatility in tgf-beta signaling through Smads.

Authors:  Xin-Hua Feng; Rik Derynck
Journal:  Annu Rev Cell Dev Biol       Date:  2005       Impact factor: 13.827

5.  Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.

Authors:  Stephanie Cambier; Stephanie Gline; Dezhi Mu; Rodney Collins; Jun Araya; Gregory Dolganov; Steven Einheber; Nancy Boudreau; Stephen L Nishimura
Journal:  Am J Pathol       Date:  2005-06       Impact factor: 4.307

Review 6.  Transforming growth factor-beta and Smad signalling in kidney diseases.

Authors:  Wansheng Wang; Vijay Koka; Hui Y Lan
Journal:  Nephrology (Carlton)       Date:  2005-02       Impact factor: 2.506

7.  Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.

Authors:  Joseph H McCarty; Adam Lacy-Hulbert; Alain Charest; Roderick T Bronson; Denise Crowley; David Housman; John Savill; Jürgen Roes; Richard O Hynes
Journal:  Development       Date:  2004-12-02       Impact factor: 6.868

8.  Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.

Authors:  Philippe Bonniaud; Martin Kolb; Tom Galt; Jennifer Robertson; Clinton Robbins; Martin Stampfli; Carol Lavery; Peter J Margetts; Anita B Roberts; Jack Gauldie
Journal:  J Immunol       Date:  2004-08-01       Impact factor: 5.422

9.  Molecular interactions that confer latency to transforming growth factor-beta.

Authors:  Geoffrey D Young; Joanne E Murphy-Ullrich
Journal:  J Biol Chem       Date:  2004-06-18       Impact factor: 5.157

10.  Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

Authors:  Justin P Annes; Yan Chen; John S Munger; Daniel B Rifkin
Journal:  J Cell Biol       Date:  2004-06-07       Impact factor: 10.539
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  67 in total

Review 1.  Integrins and extracellular matrix in mechanotransduction.

Authors:  Martin Alexander Schwartz
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-11-17       Impact factor: 10.005

2.  The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

Authors:  Bradley P Sullivan; Paul H Weinreb; Shelia M Violette; James P Luyendyk
Journal:  Am J Pathol       Date:  2010-10-29       Impact factor: 4.307

3.  Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.

Authors:  Shenaz Khan; Sujata Lakhe-Reddy; Joseph H McCarty; Christine M Sorenson; Nader Sheibani; Louis F Reichardt; Jane H Kim; Bingcheng Wang; John R Sedor; Jeffrey R Schelling
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

4.  Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.

Authors:  Mario A Shields; Surabhi Dangi-Garimella; Seth B Krantz; David J Bentrem; Hidayatullah G Munshi
Journal:  J Biol Chem       Date:  2011-02-02       Impact factor: 5.157

5.  Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.

Authors:  Cecilia Marmai; Rachel E Sutherland; Kevin K Kim; Gregory M Dolganov; Xiaohui Fang; Sophia S Kim; Shuwei Jiang; Jeffery A Golden; Charles W Hoopes; Michael A Matthay; Harold A Chapman; Paul J Wolters
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-04-15       Impact factor: 5.464

6.  TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation.

Authors:  Ambra Pozzi; Roy Zent
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

Review 7.  Wounds that will not heal: pervasive cellular reprogramming in cancer.

Authors:  Jung S Byun; Kevin Gardner
Journal:  Am J Pathol       Date:  2013-02-22       Impact factor: 4.307

Review 8.  Integrins in Wound Healing.

Authors:  Leeni Koivisto; Jyrki Heino; Lari Häkkinen; Hannu Larjava
Journal:  Adv Wound Care (New Rochelle)       Date:  2014-12-01       Impact factor: 4.730

9.  Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis.

Authors:  Norihiko Sakai; Andrew M Tager
Journal:  Biochim Biophys Acta       Date:  2013-03-14

10.  Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives.

Authors:  Boris Hinz; Giulio Gabbiani
Journal:  F1000 Biol Rep       Date:  2010-11-11
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