| Literature DB >> 19729173 |
Akiyuki Uzawa1, Masahiro Mori, Yuhta Iwai, Makoto Kobayashi, Sei Hayakawa, Naoki Kawaguchi, Satoshi Kuwabara.
Abstract
We describe 2 patients who developed anti-aquaporin-4 antibody-positive neuromyelitis optica (NMO) following the development of anti-acetylcholine receptor antibody-positive myasthenia gravis (MG). A literature review of 13 similar cases in addition to the present 2 cases of NMO with MG showed predominance among Asian women and frequent development of NMO following thymectomy for MG. Moreover, in one of our patients, serial assays of anti-aquaporin-4 antibody and anti-acetylcholine receptor antibody were performed. Accumulating evidence for the coexistence of NMO and MG suggests that a common immunopathogenesis of NMO and MG may exist, and the association of NMO with MG may be more frequent than hitherto believed.Entities:
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Year: 2009 PMID： 19729173 DOI： 10.1016/j.jns.2009.08.040
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181