Literature DB >> 19729074

Dihydropyridines: evaluation of their current and future pharmacological applications.

Najmeh Edraki1, Ahmad R Mehdipour, Mehdi Khoshneviszadeh, Ramin Miri.   

Abstract

The 1,4-dihydropyridines (DHPs), a class of drugs, possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel-modulating agents and have experienced widespread use in the treatment of cardiovascular disease. Moreover, it has been demonstrated that DHPs could prove to be highly important as multidrug-resistance-reversing agents in cancer chemotherapy. Recent reports suggest that this class also has other notable activities, particularly as antimycobacterial and anticonvulsant agents. Finally, it might be possible for the DHP motif to serve as a scaffold for other pharmacological applications.

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Year:  2009        PMID： 19729074     DOI： 10.1016/j.drudis.2009.08.004

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  25 in total

1.  Small molecules intercept Notch signaling and the early secretory pathway.

Authors:  Andreas Krämer; Torben Mentrup; Bertrand Kleizen; Eric Rivera-Milla; Daniela Reichenbach; Christoph Enzensperger; Richard Nohl; Eric Täuscher; Helmar Görls; Aspasia Ploubidou; Christoph Englert; Oliver Werz; Hans-Dieter Arndt; Christoph Kaether
Journal:  Nat Chem Biol       Date:  2013-09-29       Impact factor: 15.040

2.  Lewis acid catalysis and Green oxidations: sequential tandem oxidation processes induced by Mn-hyperaccumulating plants.

Authors:  Vincent Escande; Brice-Loïc Renard; Claude Grison
Journal:  Environ Sci Pollut Res Int       Date:  2014-09-30       Impact factor: 4.223

3.  Atom-efficient regioselective 1,2-dearomatization of functionalized pyridines by an earth-abundant organolanthanide catalyst.

Authors:  Alexander S Dudnik; Victoria L Weidner; Alessandro Motta; Massimiliano Delferro; Tobin J Marks
Journal:  Nat Chem       Date:  2014-10-19       Impact factor: 24.427

4.  1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain.

Authors:  Chris Bladen; Vinicius M Gadotti; Miyase G Gündüz; N Daniel Berger; Rahime Şimşek; Cihat Şafak; Gerald W Zamponi
Journal:  Pflugers Arch       Date:  2014-07-03       Impact factor: 3.657

5.  Molecular simulations study of novel 1,4-dihydropyridines derivatives with a high selectivity for Cav3.1 calcium channel.

Authors:  Xiaoguang Liu; Hui Yu; Xi Zhao; Xu-Ri Huang
Journal:  Protein Sci       Date:  2015-08-25       Impact factor: 6.725

6.  Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Authors:  Erik Willems; Joaquim Cabral-Teixeira; Dennis Schade; Wenqing Cai; Patrick Reeves; Paul J Bushway; Marion Lanier; Christopher Walsh; Tomas Kirchhausen; Juan Carlos Izpisua Belmonte; John Cashman; Mark Mercola
Journal:  Cell Stem Cell       Date:  2012-08-03       Impact factor: 24.633

7.  Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity.

Authors:  Chris Bladen; Miyase Gözde Gündüz; Rahime Şimşek; Cihat Şafak; Gerald W Zamponi
Journal:  Pflugers Arch       Date:  2013-10-23       Impact factor: 3.657

8.  Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

Authors:  Dennis Schade; Marion Lanier; Erik Willems; Karl Okolotowicz; Paul Bushway; Christine Wahlquist; Cynthia Gilley; Mark Mercola; John R Cashman
Journal:  J Med Chem       Date:  2012-11-06       Impact factor: 7.446

9.  Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: design, synthesis, biological evaluation and molecular docking analysis.

Authors:  S Ranjbar; O Firuzi; N Edraki; O Shahraki; L Saso; M Khoshneviszadeh; R Miri
Journal:  Medchemcomm       Date:  2017-08-23       Impact factor: 3.597

10.  An umpolung approach to the hydroboration of pyridines: a novel and efficient synthesis of N-H 1,4-dihydropyridines.

Authors:  Huan Yang; Li Zhang; Fei-Yu Zhou; Lei Jiao
Journal:  Chem Sci       Date:  2019-12-03       Impact factor: 9.825
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