Literature DB >> 1972714

T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer.

K E Lundin1, L M Sollid, E Qvigstad, G Markussen, H A Gjertsen, J Ek, E Thorsby.   

Abstract

The HLA-associated susceptibility to develop celiac disease may to a large extent be attributed to the combination of particular DQA1 and DQB1 genes, i.e., the DQA1*0501 and DBQB1*0201 alleles, located either in cis position (on the DR3DQw2 haplotype) or in trans position (DR5DQw7/DR7DQw2 heterozygous individuals). We report three alloreactive T lymphocyte clones that recognize an HLA-DQ alpha/beta heterodimer both when the DQA1*0501 and DQB1*0201 alleles are located in cis or in trans position. Thus, the celiac disease associated DQA1 and DQB1 genes encode a functionally expressed DQ alpha/beta heterodimer.

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Year:  1990        PMID： 1972714

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  11 in total

1.  Serological markers and HLA-DQ2 haplotype among first-degree relatives of celiac patients. Catalonian Coeliac Disease Study Group.

Authors:  C Farré; P Humbert; P Vilar; V Varea; X Aldeguer; J Carnicer; M Carballo; M A Gassull
Journal:  Dig Dis Sci       Date:  1999-11       Impact factor: 3.199

Review 2.  Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes.

Authors:  C Osorio; N Wen; R Gemini; R Zemetra; D von Wettstein; S Rustgi
Journal:  Funct Integr Genomics       Date:  2012-06-26       Impact factor: 3.410

Review 3.  Celiac disease: pathogenesis of a model immunogenetic disease.

Authors:  Martin F Kagnoff
Journal:  J Clin Invest       Date:  2007-01       Impact factor: 14.808

4.  Clinical and histopathological correlation of duodenal biopsy with IgA anti-tissue transglutaminase titers in children with celiac disease.

Authors:  Malobika Bhattacharya; Avinash Lomash; Puja Sakhuja; Anand Prakash Dubey; Seema Kapoor
Journal:  Indian J Gastroenterol       Date:  2014-05-24

5.  HLA dosage effect in narcolepsy with cataplexy.

Authors:  Astrid van der Heide; Willem Verduijn; Geert W Haasnoot; Jos J M Drabbels; Gert J Lammers; Frans H J Claas
Journal:  Immunogenetics       Date:  2014-10-03       Impact factor: 2.846

6.  Binding of gluten-derived peptides to the HLA-DQ2 (alpha1*0501, beta1*0201) molecule, assessed in a cellular assay.

Authors:  R G Shidrawi; N D Parnell; P J Ciclitira; P Travers; G Evan; S Rosen-Bronson
Journal:  Clin Exp Immunol       Date:  1998-01       Impact factor: 4.330

Review 7.  Cutaneous manifestations in celiac disease.

Authors:  L Abenavoli; I Proietti; L Leggio; A Ferrulli; L Vonghia; R Capizzi; M Rotoli; P L Amerio; G Gasbarrini; G Addolorato
Journal:  World J Gastroenterol       Date:  2006-02-14       Impact factor: 5.742

8.  Serum autoantibodies directed against transglutaminase-2 have a low avidity compared with alloantibodies against gliadin in coeliac disease.

Authors:  K A Gelderman; A C A D Drop; L A Trouw; H J Bontkes; G Bouma; I M W van Hoogstraten; B M E von Blomberg
Journal:  Clin Exp Immunol       Date:  2014-07       Impact factor: 4.330

9.  Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.

Authors:  K E Lundin; H Scott; T Hansen; G Paulsen; T S Halstensen; O Fausa; E Thorsby; L M Sollid
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307

Review 10.  Fast food fever: reviewing the impacts of the Western diet on immunity.

Authors:  Ian A Myles
Journal:  Nutr J       Date:  2014-06-17       Impact factor: 3.271
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