PURPOSE/ OBJECTIVES: To examine the relationships among fatigue and physical and mental quality of life (QOL) and different adjuvant chemotherapy regimens in patients with stage I-IIIA breast cancer prior to, during, and after treatment. DESIGN: Longitudinal, descriptive design embedded in a randomized, clinical trial. SETTING:Outpatient oncology clinics in the midwestern United States. SAMPLE: 196 postoperative women, mean age of 52 years, receivinganthracycline-based chemotherapy regimens: dose-dense taxane, dose-standard taxane, or dose-standard without taxane. METHODS: The Piper Fatigue Scale and Medical Outcomes Study SF-36(R) (v.2) Survey were completed 48 hours prior to treatment 1, at treatments 4 and 8, and 30 days after the final treatment. MAIN RESEARCH VARIABLES: Fatigue, adjuvant chemotherapy regimen, and QOL. FINDINGS:Fatigue and mental QOL changed significantly over time for all regimens, but the patterns of change did not differ based on regimen. Physical QOL changed significantly over time for all regimens, and the pattern of change differed based on whether taxanes were received. Higher fatigue was correlated with lower physical and mental QOL prior to and 30 days after the final treatment, regardless of regimen. CONCLUSIONS: Women who receive taxanes are at higher risk for lower physical QOL over time. Higher fatigue was associated with lower QOL regardless of the chemotherapy regimens. IMPLICATIONS FOR NURSING: Clinicians should screen patients for fatigue and assess for contributing factors at clinic visits. Methods to integrate evidence-based fatigue interventions into practice should be tested and outcomes evaluated.
RCT Entities:
PURPOSE/ OBJECTIVES: To examine the relationships among fatigue and physical and mental quality of life (QOL) and different adjuvant chemotherapy regimens in patients with stage I-IIIA breast cancer prior to, during, and after treatment. DESIGN: Longitudinal, descriptive design embedded in a randomized, clinical trial. SETTING:Outpatient oncology clinics in the midwestern United States. SAMPLE: 196 postoperative women, mean age of 52 years, receiving anthracycline-based chemotherapy regimens: dose-dense taxane, dose-standard taxane, or dose-standard without taxane. METHODS: The Piper Fatigue Scale and Medical Outcomes Study SF-36(R) (v.2) Survey were completed 48 hours prior to treatment 1, at treatments 4 and 8, and 30 days after the final treatment. MAIN RESEARCH VARIABLES: Fatigue, adjuvant chemotherapy regimen, and QOL. FINDINGS:Fatigue and mental QOL changed significantly over time for all regimens, but the patterns of change did not differ based on regimen. Physical QOL changed significantly over time for all regimens, and the pattern of change differed based on whether taxanes were received. Higher fatigue was correlated with lower physical and mental QOL prior to and 30 days after the final treatment, regardless of regimen. CONCLUSIONS:Women who receive taxanes are at higher risk for lower physical QOL over time. Higher fatigue was associated with lower QOL regardless of the chemotherapy regimens. IMPLICATIONS FOR NURSING: Clinicians should screen patients for fatigue and assess for contributing factors at clinic visits. Methods to integrate evidence-based fatigue interventions into practice should be tested and outcomes evaluated.
Authors: Fay Wright; Gail D'Eramo Melkus; Marilyn Hammer; Brian L Schmidt; M Tish Knobf; Steven M Paul; Frances Cartwright; Judy Mastick; Bruce A Cooper; Lee-May Chen; Michelle Melisko; Jon D Levine; Kord Kober; Bradley E Aouizerat; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2015-03-28 Impact factor: 3.612
Authors: Fay Wright; Gail D'Eramo Melkus; Marilyn Hammer; Brian L Schmidt; M Tish Knobf; Steven M Paul; Frances Cartwright; Judy Mastick; Bruce A Cooper; Lee-May Chen; Michelle Melisko; Jon D Levine; Kord Kober; Bradley E Aouizerat; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2015-03-28 Impact factor: 3.612
Authors: Marylin J Dodd; Maria H Cho; Christine Miaskowski; Patricia L Painter; Steven M Paul; Bruce A Cooper; John Duda; Joanne Krasnoff; Kayee A Bank Journal: Cancer Nurs Date: 2010 Jul-Aug Impact factor: 2.592
Authors: Carol M Moinpour; Gary W Donaldson; Kimberly M Davis; Arnold L Potosky; Roxanne E Jensen; Julie R Gralow; Anthony L Back; Jimmy J Hwang; Jihye Yoon; Debra L Bernard; Deena R Loeffler; Nan E Rothrock; Ron D Hays; Bryce B Reeve; Ashley Wilder Smith; Elizabeth A Hahn; David Cella Journal: Qual Life Res Date: 2016-07-28 Impact factor: 4.147
Authors: Stephanie J Sohl; Beverly Levine; L Douglas Case; Suzanne C Danhauer; Nancy E Avis Journal: Health Psychol Date: 2013-05-13 Impact factor: 4.267
Authors: Fay Wright; Bruce A Cooper; Yvette P Conley; Marilyn J Hammer; Lee-May Chen; Steven M Paul; Jon D Levine; Christine Miaskowski; Kord M Kober Journal: Fatigue Date: 2017-05-18