| Literature DB >> 19726084 |
Abstract
The TCL1 mouse has been proposed as a mouse model for chronic lymphocytic leukemia. This review details how it resembles the aggressive form of the disease rather than the more common indolent form. Although fulfilled predictions in the human disease based on investigations in the mouse model are at present lacking, there are remarkable similarities between human and mouse leukemias that have led to interesting observations on the pathophysiology of chronic lymphocytic leukemia and have identified putative therapeutic targets. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19726084 DOI： 10.1016/j.leukres.2009.08.004
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156