Literature DB >> 19725296

Fecal diversion in perirectal fistulizing Crohn's disease is an underutilized and potentially temporary means of successful treatment.

Kellee L Rehg1, Jaime E Sanchez, Beth R Krieger, Jorge E Marcet.   

Abstract

The purpose of this study was to determine the outcome of patients treated with fecal diversion for perirectal fistulizing Crohn's disease. Thirty-nine patients were identified and followed for an average of 60 months. Patients were divided into two groups based on surgical treatment: local surgical treatment only and fecal diversion in addition to local surgical therapy. Thirteen patients (33%) underwent fecal diversion due to the severity of their disease. Eleven of these patients (85%) had complete resolution of their fistulas and only two (15%) required proctectomy. In contrast, only five out of 26 patients (19%) who underwent local surgical procedures alone had complete perirectal disease resolution. Intestinal continuity was restored in six patients (46%) and three of these patients (50%) remained disease free. The remaining three patients had disease recurrence, which required additional local procedures in one patient (17%), but with eventual resolution; the other two patients (33%) necessitated rediversion. Our data suggest that fecal diversion is a viable treatment option for severe perirectal fistulizing Crohn's disease and may be associated with a higher rate of resolution than local surgical treatment alone. In addition, we demonstrate a higher rate of successful intestinal continuity restoration than is typically reported.

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Year:  2009        PMID: 19725296

Source DB:  PubMed          Journal:  Am Surg        ISSN: 0003-1348            Impact factor:   0.688


  10 in total

Review 1.  British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.

Authors:  Christopher Andrew Lamb; Nicholas A Kennedy; Tim Raine; Philip Anthony Hendy; Philip J Smith; Jimmy K Limdi; Bu'Hussain Hayee; Miranda C E Lomer; Gareth C Parkes; Christian Selinger; Kevin J Barrett; R Justin Davies; Cathy Bennett; Stuart Gittens; Malcolm G Dunlop; Omar Faiz; Aileen Fraser; Vikki Garrick; Paul D Johnston; Miles Parkes; Jeremy Sanderson; Helen Terry; Daniel R Gaya; Tariq H Iqbal; Stuart A Taylor; Melissa Smith; Matthew Brookes; Richard Hansen; A Barney Hawthorne
Journal:  Gut       Date:  2019-09-27       Impact factor: 23.059

2.  Alterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.

Authors:  Holger Schäffler; Annika Kaschitzki; Christian Alberts; Peggy Bodammer; Karen Bannert; Thomas Köller; Philipp Warnke; Bernd Kreikemeyer; Georg Lamprecht
Journal:  Int J Colorectal Dis       Date:  2016-03-07       Impact factor: 2.571

3.  The Use of Temporary Fecal Diversion in Colonic and Perianal Crohn's Disease Does Not Improve Outcomes.

Authors:  Andrea C Bafford; Anastasiya Latushko; Natasha Hansraj; Guruprasad Jambaulikar; Leyla J Ghazi
Journal:  Dig Dis Sci       Date:  2017-05-26       Impact factor: 3.199

4.  Endorectal Advancement Flaps for Perianal Fistulae in Crohn's Disease: Careful Patient Selection Leads to Optimal Outcomes.

Authors:  Michelle T Roper; Stephen M Trinidad; Sonia L Ramamoorthy; Lisa A Parry; Nicole E Lopez; Sergey Khaitov; Randolph Steinhagen; Samuel G Eisenstein
Journal:  J Gastrointest Surg       Date:  2019-04-12       Impact factor: 3.452

Review 5.  Role of Fecal Diversion in Complex Crohn's Disease.

Authors:  John P Burke
Journal:  Clin Colon Rectal Surg       Date:  2019-07-02

6.  Managing perianal Crohn's fistula in the anti-TNFα era.

Authors:  P Tozer; D W Borowski; A Gupta; N Yassin; R Phillips; A Hart
Journal:  Tech Coloproctol       Date:  2015-08-12       Impact factor: 3.781

Review 7.  Second Korean guidelines for the management of Crohn's disease.

Authors:  Jae Jun Park; Suk-Kyun Yang; Byong Duk Ye; Jong Wook Kim; Dong Il Park; Hyuk Yoon; Jong Pil Im; Kang Moon Lee; Sang Nam Yoon; Heeyoung Lee
Journal:  Intest Res       Date:  2017-01-31

Review 8.  Evaluation of animal models of Crohn's disease with anal fistula (Review).

Authors:  Shuangshuang Lu; Keyuan Zhu; Yongxin Guo; Enjing Wang; Jin Huang
Journal:  Exp Ther Med       Date:  2021-07-08       Impact factor: 2.447

9.  Temporary fecal diversion in the management of colorectal and perianal Crohn's disease.

Authors:  Rudolf Mennigen; Britta Heptner; Norbert Senninger; Emile Rijcken
Journal:  Gastroenterol Res Pract       Date:  2015-01-11       Impact factor: 2.260

10.  Dysbiosis in a canine model of human fistulizing Crohn's disease.

Authors:  Ana Maldonado-Contreras; Lluís Ferrer; Caitlin Cawley; Sarah Crain; Shakti Bhattarai; Juan Toscano; Doyle V Ward; Andrew Hoffman
Journal:  Gut Microbes       Date:  2020-07-30
  10 in total

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