Literature DB >> 1972432

Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease.

D P Geaney1, N Soper, B J Shepstone, P J Cowen.   

Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

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Year:  1990        PMID： 1972432     DOI： 10.1016/0140-6736(90)93028-n

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  22 in total

1.  Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.

Authors:  M Yamada; K G Lamping; A Duttaroy; W Zhang; Y Cui; F P Bymaster; D L McKinzie; C C Felder; C X Deng; F M Faraci; J Wess
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-13       Impact factor: 11.205

2.  Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?

Authors:  Tamara G Fong; Sharon K Inouye; Weiying Dai; Daniel Z Press; David C Alsop
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Authors:  Christopher I Moore; Rosa Cao
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Review 4.  The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.

Authors:  Harald Hampel; M-Marsel Mesulam; A Claudio Cuello; Martin R Farlow; Ezio Giacobini; George T Grossberg; Ara S Khachaturian; Andrea Vergallo; Enrica Cavedo; Peter J Snyder; Zaven S Khachaturian
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5.  Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.

Authors:  Omar M Al-Janabi; Christopher A Brown; Ahmed A Bahrani; Erin L Abner; Justin M Barber; Brian T Gold; Larry B Goldstein; Ronan R Murphy; Peter T Nelson; Nathan F Johnson; Leslie M Shaw; Charles D Smith; John Q Trojanowski; Donna M Wilcock; Gregory A Jicha
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Review 6.  Functional imaging of the brain in the evaluation of drug response and its application to the study of aging.

Authors:  C A Bryant; S H Jackson
Journal:  Drugs Aging       Date:  1998-09       Impact factor: 3.923

Review 7.  Cholinergic modulation of cognition: insights from human pharmacological functional neuroimaging.

Authors:  Paul Bentley; Jon Driver; Raymond J Dolan
Journal:  Prog Neurobiol       Date:  2011-06-17       Impact factor: 11.685

8.  Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory.

Authors:  M L Furey; P Pietrini; J V Haxby; G E Alexander; H C Lee; J VanMeter; C L Grady; U Shetty; S I Rapoport; M B Schapiro; U Freo
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

9.  A neurochemical approach for studying response to acetylcholine in Alzheimer's disease.

Authors:  J T Alder; I P Chessell; D M Bowen
Journal:  Neurochem Res       Date:  1995-07       Impact factor: 3.996

10.  Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.

Authors:  P M Grasby; K J Friston; C Bench; P J Cowen; C D Frith; P F Liddle; R S Frackowiak; R J Dolan
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
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