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Literature DB >> 19724260

Aurora A moonlights in neurite extension.

Abstract

Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.

Entities: CellLine Chemical Disease Gene Species

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Year: 2009 PMID： 19724260 PMCID： PMC4902652 DOI： 10.1038/ncb0909-1053

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

12 in total

1. Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.

Authors: Song-Hai Shi; Lily Yeh Jan; Yuh-Nung Jan
Journal: Cell Date: 2003-01-10 Impact factor: 41.582

Review 2. Cytoskeletal dynamics and transport in growth cone motility and axon guidance.

Authors: Erik W Dent; Frank B Gertler
Journal: Neuron Date: 2003-10-09 Impact factor: 17.173

3. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.

Authors: Daisuke Mori; Yoshihisa Yano; Kazuhito Toyo-oka; Noriyuki Yoshida; Masami Yamada; Masami Muramatsu; Dongwei Zhang; Hideyuki Saya; Yoko Y Toyoshima; Kazuhisa Kinoshita; Anthony Wynshaw-Boris; Shinji Hirotsune
Journal: Mol Cell Biol Date: 2006-10-23 Impact factor: 4.272

4. An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.

Authors: Daisuke Mori; Masami Yamada; Yuko Mimori-Kiyosue; Yasuhito Shirai; Atsushi Suzuki; Shigeo Ohno; Hideaki Saya; Anthony Wynshaw-Boris; Shinji Hirotsune
Journal: Nat Cell Biol Date: 2009-08-09 Impact factor: 28.824

5. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.

Authors: Atsushi Kamiya; Toshifumi Tomoda; Jennifer Chang; Manabu Takaki; Caixin Zhan; Masahiko Morita; Matthew B Cascio; Sarah Elashvili; Hiroyuki Koizumi; Yasukazu Takanezawa; Faith Dickerson; Robert Yolken; Hiroyuki Arai; Akira Sawa
Journal: Hum Mol Genet Date: 2006-10-11 Impact factor: 6.150

Review 6. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity.

Authors: Christopher L Frank; Li-Huei Tsai
Journal: Neuron Date: 2009-05-14 Impact factor: 17.173

7. Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.

Authors: Tianzhi Shu; Ramses Ayala; Minh-Dang Nguyen; Zhigang Xie; Joseph G Gleeson; Li-Huei Tsai
Journal: Neuron Date: 2004-10-14 Impact factor: 17.173

8. HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

Authors: Elena N Pugacheva; Sandra A Jablonski; Tiffiney R Hartman; Elizabeth P Henske; Erica A Golemis
Journal: Cell Date: 2007-06-29 Impact factor: 41.582

9. Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.

Authors: Frederik Wirtz-Peitz; Takashi Nishimura; Juergen A Knoblich
Journal: Cell Date: 2008-10-03 Impact factor: 41.582

10. Human TPX2 is required for targeting Aurora-A kinase to the spindle.

Authors: Thomas A Kufer; Herman H W Silljé; Roman Körner; Oliver J Gruss; Patrick Meraldi; Erich A Nigg
Journal: J Cell Biol Date: 2002-08-12 Impact factor: 10.539

3 in total

Review 1. Issues in interpreting the in vivo activity of Aurora-A.

Authors: Elena Shagisultanova; Roland L Dunbrack; Erica A Golemis
Journal: Expert Opin Ther Targets Date: 2014-11-11 Impact factor: 6.902

Review 2. TPX2: of spindle assembly, DNA damage response, and cancer.

Authors: Gernot Neumayer; Camille Belzil; Oliver J Gruss; Minh Dang Nguyen
Journal: Cell Mol Life Sci Date: 2014-02-21 Impact factor: 9.261

Review 3. Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.

Authors: Sara Anna Bonini; Andrea Mastinu; Giulia Ferrari-Toninelli; Maurizio Memo
Journal: Int J Mol Sci Date: 2017-07-26 Impact factor: 5.923

3 in total