Literature DB >> 19723627

Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.

Fangming Tang1, John Kokontis, Yuting Lin, Shutsung Liao, Anning Lin, Jialing Xiang.   

Abstract

The male hormone androgen is a growth/survival factor for its target tissues or organs. Yet, the underlying mechanism is incompletely understood. Here, we report that androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. Inhibition by androgen requires the transcription activity of androgen receptor (AR) and de novo protein synthesis. Androgen.AR induces expression of p21 that in turn inhibits tumor necrosis factor alpha-induced JNK and apoptosis. Furthermore, genetic interruption of p21 alleles abolishes the inhibition by androgen. Our results reveal a novel cross-talk between androgen x AR and JNK, thereby providing a molecular mechanism underlying the survival function of androgen.

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Year:  2009        PMID： 19723627      PMCID： PMC2781650          DOI： 10.1074/jbc.M109.042994

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  45 in total

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Review 7.  Molecular action of androgen in the normal and neoplastic prostate.

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  9 in total

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  9 in total

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