Adejuwon Adewale Adeneye1, Olufunmilayo Olaide Adeyemi. 1. Department of Pharmacology, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria. adeneye2001@yahoo.com
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: In African traditional medicine, water decoction made from the dry seeds of Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus. AIM: In the present study, the antihyperglycaemic activity of the seed aqueous extract of Hunteria umbellate (K. Schum) Hallier f. (HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats. MATERIALS AND METHODS: Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1 mg/kg of glibenclamide, 50 mg/kg, 100 mg/kg and 200 mg/kg of HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA(1c), serum TG and TC, and insulin resistance indices were investigated. RESULTS: Data generated in the current study showed that glibenclamide and graded oral doses of HU caused significant dose related (p < 0.05, < 0.01 and < 0.001) reductions in FBG when compared to the values obtained for the model control (Group II) rats. Similarly, daily oral administration of 66.7 g/kg fructose to rats for 8 weeks was associated with significant (p < 0.001) hyperglycaemia, elevations in plasma HbA(1c), free insulin, fasting insulin resistance indices, serum TG, and cholesterol. However, concomitant oral treatments with 1mg/kg of glibenclamide, 50 mg/kg, 100 mg/kg, and 200 mg/kg of HU extract significantly and dose dependently (p < 0.05, < 0.01 and < 0.001) attenuated development of hyperglycaemia, decreased levels of plasma HbA(1c), free insulin, and serum triglyceride and cholesterol, in the Groups III, IV, V and VI rats, respectively, when compared to fructose-induced hyperglycaemic (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats. CONCLUSION: Results of this study suggest that the hypoglycaemic and antihyperlipidaemic effects of HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia.
ETHNOPHARMACOLOGICAL RELEVANCE: In African traditional medicine, water decoction made from the dry seeds of Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus. AIM: In the present study, the antihyperglycaemic activity of the seed aqueous extract of Hunteria umbellate (K. Schum) Hallier f. (HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats. MATERIALS AND METHODS:Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1 mg/kg of glibenclamide, 50 mg/kg, 100 mg/kg and 200 mg/kg of HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA(1c), serum TG and TC, and insulin resistance indices were investigated. RESULTS: Data generated in the current study showed that glibenclamide and graded oral doses of HU caused significant dose related (p < 0.05, < 0.01 and < 0.001) reductions in FBG when compared to the values obtained for the model control (Group II) rats. Similarly, daily oral administration of 66.7 g/kg fructose to rats for 8 weeks was associated with significant (p < 0.001) hyperglycaemia, elevations in plasma HbA(1c), free insulin, fasting insulin resistance indices, serum TG, and cholesterol. However, concomitant oral treatments with 1mg/kg of glibenclamide, 50 mg/kg, 100 mg/kg, and 200 mg/kg of HU extract significantly and dose dependently (p < 0.05, < 0.01 and < 0.001) attenuated development of hyperglycaemia, decreased levels of plasma HbA(1c), free insulin, and serum triglyceride and cholesterol, in the Groups III, IV, V and VI rats, respectively, when compared to fructose-induced hyperglycaemic (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats. CONCLUSION: Results of this study suggest that the hypoglycaemic and antihyperlipidaemic effects of HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia.
Authors: Sandra M Barbalho; Débora C Damasceno; Ana Paula Machado Spada; Miréia Palhares; Karla Aparecida Martuchi; Marie Oshiiwa; Viviane Sazaki; Vanessa Sellis da Silva Journal: Exp Diabetes Res Date: 2011-01-23