Literature DB >> 19722841

Pathogen recognition by DC-SIGN shapes adaptive immunity.

Teunis B H Geijtenbeek1, Jeroen den Dunnen, Sonja I Gringhuis.   

Abstract

Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. This diversity is mediated by cooperation between different pattern recognition receptors that are triggered by specific pathogens. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition receptor with a broad pathogen recognition specificity as a result of its affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse immune responses to different pathogens, such as bacteria, fungi, helminths and viruses. Recent data show that DC-SIGN triggering by pathogens modulates Toll-like receptor signaling at the level of nuclear factor-kappaB. In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens.

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Year:  2009        PMID： 19722841     DOI： 10.2217/fmb.09.51

Source DB:  PubMed          Journal:  Future Microbiol        ISSN： 1746-0913            Impact factor:   3.165


  33 in total

1.  The formation and stability of DC-SIGN microdomains require its extracellular moiety.

Authors:  Ping Liu; Xiang Wang; Michelle S Itano; Aaron K Neumann; Ken Jacobson; Nancy L Thompson
Journal:  Traffic       Date:  2012-02-27       Impact factor: 6.215

2.  Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins.

Authors:  Kouki Morizono; Amy Ku; Yiming Xie; Airi Harui; Sam K P Kung; Michael D Roth; Benhur Lee; Irvin S Y Chen
Journal:  J Virol       Date:  2010-05-19       Impact factor: 5.103

3.  A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms.

Authors:  Yanchen Zhou; Kai Lu; Susanne Pfefferle; Stephanie Bertram; Ilona Glowacka; Christian Drosten; Stefan Pöhlmann; Graham Simmons
Journal:  J Virol       Date:  2010-06-23       Impact factor: 5.103

Review 4.  Natural and Induced Tolerogenic Dendritic Cells.

Authors:  Courtney A Iberg; Daniel Hawiger
Journal:  J Immunol       Date:  2020-02-15       Impact factor: 5.422

5.  Measles virus glycoprotein-pseudotyped lentiviral vectors are highly superior to vesicular stomatitis virus G pseudotypes for genetic modification of monocyte-derived dendritic cells.

Authors:  J-M Humbert; C Frecha; F Amirache Bouafia; T H N'Guyen; S Boni; F-L Cosset; E Verhoeyen; F Halary
Journal:  J Virol       Date:  2012-02-15       Impact factor: 5.103

Review 6.  Measles virus-induced immunosuppression: from effectors to mechanisms.

Authors:  Elita Avota; Evelyn Gassert; Sibylle Schneider-Schaulies
Journal:  Med Microbiol Immunol       Date:  2010-04-08       Impact factor: 3.402

7.  Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination.

Authors:  Tao Du; Kai Hu; Jun Yang; Jing Jin; Chang Li; Daniel Stieh; George E Griffin; Robin J Shattock; Qinxue Hu
Journal:  Antimicrob Agents Chemother       Date:  2012-06-11       Impact factor: 5.191

8.  Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells.

Authors:  Filippo Veglia; Ester Sciaraffia; Antonella Riccomi; Dora Pinto; Donatella R M Negri; Maria Teresa De Magistris; Silvia Vendetti
Journal:  Infect Immun       Date:  2010-12-13       Impact factor: 3.441

9.  Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

Authors:  Teresa R Johnson; Jason S McLellan; Barney S Graham
Journal:  J Virol       Date:  2011-11-16       Impact factor: 5.103

10.  Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.

Authors:  Annelies W Mesman; Esther M Zijlstra-Willems; Tanja M Kaptein; Rik L de Swart; Meredith E Davis; Martin Ludlow; W Paul Duprex; Michaela U Gack; Sonja I Gringhuis; Teunis B H Geijtenbeek
Journal:  Cell Host Microbe       Date:  2014-07-09       Impact factor: 21.023
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