OBJECTIVE: The aim of this review was to summarize our present knowledge about calcium phosphate (CaP) coatings on implants with respect to their topographical appearance at micrometer as well as nanometer level and also the reported influence on bone healing. MATERIAL AND METHODS: The PubMed database was used with the key words - surface roughness, CaP coating, implant, bone integration, clinical studies, experimental studies - used in different combinations. Only in vivo studies were taken into consideration. CONCLUSIONS: A significantly improved healing capacity associated with CaP-coated implants is often reported, but individual importance of the several modes of surface changes introduced, deliberately or not, is usually very difficult to interpret. Several studies claim this difference to be due to altered chemistry, but in many the result may equally well be dependent on the surface topography. The few studies that have been published indicate that nanometer structures have an impact on early bone healing. However, the optimal size and distribution of nanometer-sized particles or pores applied on implant surfaces is still unknown, as are the evaluation effects of micrometer roughness. Improved surface characterization is needed if we are to reveal effects dependent on isolated nanometer alterations.
OBJECTIVE: The aim of this review was to summarize our present knowledge about calcium phosphate (CaP) coatings on implants with respect to their topographical appearance at micrometer as well as nanometer level and also the reported influence on bone healing. MATERIAL AND METHODS: The PubMed database was used with the key words - surface roughness, CaP coating, implant, bone integration, clinical studies, experimental studies - used in different combinations. Only in vivo studies were taken into consideration. CONCLUSIONS: A significantly improved healing capacity associated with CaP-coated implants is often reported, but individual importance of the several modes of surface changes introduced, deliberately or not, is usually very difficult to interpret. Several studies claim this difference to be due to altered chemistry, but in many the result may equally well be dependent on the surface topography. The few studies that have been published indicate that nanometer structures have an impact on early bone healing. However, the optimal size and distribution of nanometer-sized particles or pores applied on implant surfaces is still unknown, as are the evaluation effects of micrometer roughness. Improved surface characterization is needed if we are to reveal effects dependent on isolated nanometer alterations.
Authors: Martin Stefanic; Radmila Milacic; Goran Drazic; Miha Škarabot; Bojan Budič; Kristoffer Krnel; Tomaž Kosmač Journal: J Mater Sci Mater Med Date: 2014-06-12 Impact factor: 3.896
Authors: J Elizabeth Biemond; Tatiane S Eufrásio; Gerjon Hannink; Nico Verdonschot; Pieter Buma Journal: J Mater Sci Mater Med Date: 2011-02-16 Impact factor: 3.896
Authors: Estevam A Bonfante; Lukasz Witek; Nick Tovar; Marcelo Suzuki; Charles Marin; Rodrigo Granato; Paulo G Coelho Journal: Int J Biomater Date: 2012-08-27
Authors: Willian F Zambuzzi; Estevam A Bonfante; Ryo Jimbo; Mariko Hayashi; Martin Andersson; Gutemberg Alves; Esther R Takamori; Paulo J Beltrão; Paulo G Coelho; José M Granjeiro Journal: PLoS One Date: 2014-07-07 Impact factor: 3.240
Authors: Michelle Bowers; Daniel Yoo; Charles Marin; Luiz Gil; Nour Shabaka; Matt Goldstein; Malvin Janal; Nick Tovar; Ronaldo Hirata; Estevam Bonfante; Paulo Coelho Journal: Med Oral Patol Oral Cir Bucal Date: 2016-03-01