PURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. CONCLUSION: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
PURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. CONCLUSION: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
Authors: Yara D Fragoso; Tarso Adoni; Soniza V Alves-Leon; Nério D Azambuja; Amilton A Barreira; Joseph B B Brooks; Denise S D Carneiro; Margarete J Carvalho; Rinaldo Claudino; Elizabeth R Comini-Frota; Renan B Domingues; Alessandro Finkelzstejn; Paulo D Gama; Maria C B Giacomo; Sidney Gomes; Marcus V M Goncalves; Anderson K Grzesiuk; Damacio R Kaimen-Maciel; Maria F Mendes; Nivea M O Morales; Rogério R Morales; Andre Muniz; Regina M Papais-Alvarenga; Monica K F Parolin; Sonia B F Ribeiro; Heloisa H Ruocco; Fabio Siquineli; Elza D Tosta Journal: CNS Drugs Date: 2013-11 Impact factor: 5.749
Authors: Yára D Fragoso; Alessandro Finkelsztejn; Damacio R Kaimen-Maciel; Anderson K Grzesiuk; Andre S Gallina; Josiane Lopes; Nivea M O Morales; Soniza V Alves-Leon; Sandra M G de Almeida Journal: CNS Drugs Date: 2010-11 Impact factor: 5.749
Authors: Marta Giannini; Emilio Portaccio; Angelo Ghezzi; Bahia Hakiki; Luisa Pastò; Lorenzo Razzolini; Elisa Piscolla; Laura De Giglio; Carlo Pozzilli; Damiano Paolicelli; Maria Trojano; Maria Giovanna Marrosu; Francesco Patti; Loredana La Mantia; Gianluigi Mancardi; Claudio Solaro; Rocco Totaro; Maria Rosaria Tola; Giovanna De Luca; Alessandra Lugaresi; Lucia Moiola; Vittorio Martinelli; Giancarlo Comi; Maria Pia Amato Journal: BMC Neurol Date: 2012-10-22 Impact factor: 2.474