Heterotrimeric G-protein signaling and light response: Two signaling pathways coordinated for optimal adjustment to nature.

Almost all creatures have invented sophisticated mechanisms to adjust their developmental and metabolic processes to the changing light intensities in day and night. Recent findings suggest that one such mechanism is signaling via heterotrimeric G-proteins.1 The Trichoderma reesei (anamorph of Hypocrea jecorina) G-alpha subunit gene gna3 was found to be responsive to light and influenced by the light regulatory protein ENVOY.2 GNA3 significantly impacts regulation of cellulase gene expression only in light.1 While the exact mechanism of this regulation remains to be determined, first hints point to a regulation at the transcriptional level, since we observed light induced complex formation within the gna3 promotor. At least some of the components of this putatively regulatory protein complex also bind to the env1-promotor. These data indicate that the signal related by GNA3 is of light-dependent significance for H. jecorina and that the pathway of heterotrimeric G-protein signaling may be a target of the light perception machinery in fungi.