Literature DB >> 19721260

Synthesis and evaluation of pyrrolin-2-one compounds, a series of plasminogen activator inhibitor-1 inhibitors.

Hiroshi Miyazaki1, Tsuyoshi Ogiku, Hiroshi Sai, Yasunori Moritani, Akio Ohtani, Hiroshi Ohmizu.   

Abstract

A novel series of furan-2-one and pyrrolin-2-one derivatives having PAI-1 (plasminogen activator inhibitor-1) inhibitory activity were synthesized and evaluated for their antithrombotic activity in a rat arterial thrombosis model. Among the synthesized compounds, 5f (T-1776Na) was found to have good selectivity for PAI-1 over other enzymes and high antithrombotic activity.

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Year:  2009        PMID： 19721260     DOI： 10.1248/cpb.57.979

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones utilizing pyrrole Weinreb amides.

Authors:  Jessica G Greger; Sarah J P Yoon-Miller; Nathan R Bechtold; Scott A Flewelling; Jacob P MacDonald; Catherine R Downey; Eric A Cohen; Erin T Pelkey
Journal:  J Org Chem       Date:  2011-09-26       Impact factor: 4.354

2.  Synthesis of phantasmidine.

Authors:  Quan Zhou; Barry B Snider
Journal:  Org Lett       Date:  2010-12-22       Impact factor: 6.005

3.  Preparation of dibenzo[e,g]isoindol-1-ones via Scholl-type oxidative cyclization reactions.

Authors:  Amy A van Loon; Maeve K Holton; Catherine R Downey; Taryn M White; Carly E Rolph; Stephen R Bruening; Guanqun Li; Katherine M Delaney; Sarah J Pelkey; Erin T Pelkey
Journal:  J Org Chem       Date:  2014-08-25       Impact factor: 4.354
  3 in total

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