BACKGROUND: Few studies have addressed the issue of adverse drug reactions with non-protease inhibitor (PI)-based antiretroviral therapy (ART) in resource-constrained settings. We studied prospectively the incidence of adverse drug reactions with generic ART among our patients. METHODOLOGY: A total of 100 HIV-infected individuals were recruited. Patients received nevirapine (NVP) or efavirenz (EFV) with lamivudine (3TC) and zidovudine (ZDV)/stavudine (d4T). They were followed for 6 months for evidence of adverse drug reactions. RESULTS: The mean CD4 count was 114.09 +/- 60.07 cells/mm(3) (range, 12-232 cells/mm(3)). Transient gastrointestinal symptoms were most frequent. Fourteen individuals (12 receiving ZDV/d4T, 3TC, NVP and 2 receiving ZDV/d4T, 3TC, EFV) developed skin rash. Among patients receiving NVP, 25.7% developed grade 1 hepatotoxicity. Three patients had numbness in both lower limbs. Among those individuals who received EFV, 32.3% individuals had central nervous system (CNS) symptoms in the form of insomnia, vivid dreams, dizziness, and drowsiness. CONCLUSION: As the developing world increasingly uses generic ART, the clinician must be constantly vigilant for treatment-related adverse events.
BACKGROUND: Few studies have addressed the issue of adverse drug reactions with non-protease inhibitor (PI)-based antiretroviral therapy (ART) in resource-constrained settings. We studied prospectively the incidence of adverse drug reactions with generic ART among our patients. METHODOLOGY: A total of 100 HIV-infected individuals were recruited. Patients received nevirapine (NVP) or efavirenz (EFV) with lamivudine (3TC) and zidovudine (ZDV)/stavudine (d4T). They were followed for 6 months for evidence of adverse drug reactions. RESULTS: The mean CD4 count was 114.09 +/- 60.07 cells/mm(3) (range, 12-232 cells/mm(3)). Transient gastrointestinal symptoms were most frequent. Fourteen individuals (12 receiving ZDV/d4T, 3TC, NVP and 2 receiving ZDV/d4T, 3TC, EFV) developed skin rash. Among patients receiving NVP, 25.7% developed grade 1 hepatotoxicity. Three patients had numbness in both lower limbs. Among those individuals who received EFV, 32.3% individuals had central nervous system (CNS) symptoms in the form of insomnia, vivid dreams, dizziness, and drowsiness. CONCLUSION: As the developing world increasingly uses generic ART, the clinician must be constantly vigilant for treatment-related adverse events.
Authors: Charlene E Gamaldo; Alyssa Gamaldo; Jason Creighton; Rachel E Salas; Ola A Selnes; Paula M David; Gilbert Mbeo; Benjamin S Parker; Amanda Brown; Justin C McArthur; Michael T Smith Journal: J Acquir Immune Defic Syndr Date: 2013-08-15 Impact factor: 3.731
Authors: Zanjbeel Mahmood; Andrea Hammond; Rodolfo A Nunez; Michael R Irwin; April D Thames Journal: J Int Neuropsychol Soc Date: 2018-08-31 Impact factor: 2.892
Authors: Jackson K Mukonzo; Alphonse Okwera; Neoline Nakasujja; Henry Luzze; Deogratious Sebuwufu; Jasper Ogwal-Okeng; Paul Waako; Lars L Gustafsson; Eleni Aklillu Journal: BMC Infect Dis Date: 2013-06-04 Impact factor: 3.090