| Literature DB >> 19720998 |
René Maehr1, Shuibing Chen, Melinda Snitow, Thomas Ludwig, Lisa Yagasaki, Robin Goland, Rudolph L Leibel, Douglas A Melton.
Abstract
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.Entities:
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Year: 2009 PMID： 19720998 PMCID： PMC2735559 DOI： 10.1073/pnas.0906894106
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205