Literature DB >> 19720744

Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities.

Xiaoyan Wu1, Xiaocen Kong, Larry Luchsinger, Barbara D Smith, Yong Xu.   

Abstract

First identified as the master regulator of major histocompatibility complex II transcription, class II transactivator (CIITA) has since been implicated in a host of pathologies by modulating the transcription of multiple different genes. How CIITA caters to cell- and tissue-specific transcriptional needs is hotly debated and investigated. One of the possible mechanisms underlying spatiotemporal control of CIITA transcriptional activity is the posttranslational modification (PTM) machinery that refines certain amino acid residues of CIITA and hence alters its activity in response to specific cellular and environmental cues. This review discusses our current understanding of the PTM map of CIITA, how these modifications fine-tune its activity, and how the study of this area may lead to potential therapeutic strategies.

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Year:  2009        PMID： 19720744      PMCID： PMC2772741          DOI： 10.1128/MCB.00661-09

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  41 in total

1.  Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

Authors:  A Raval; T K Howcroft; J D Weissman; S Kirshner; X S Zhu; K Yokoyama; J Ting; D S Singer
Journal:  Mol Cell       Date:  2001-01       Impact factor: 17.970

2.  Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompatibility complex expression in monocytic lines.

Authors:  G Li; J A Harton; X Zhu; J P Ting
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

3.  Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis.

Authors:  T Suter; U Malipiero; L Otten; B Ludewig; A Muelethaler-Mottet; B Mach; W Reith; A Fontana
Journal:  Eur J Immunol       Date:  2000-03       Impact factor: 5.532

4.  Cutting edge: the class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression.

Authors:  T S Gourley; C H Chang
Journal:  J Immunol       Date:  2001-03-01       Impact factor: 5.422

5.  A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters.

Authors:  X S Zhu; J P Ting
Journal:  Mol Cell Biol       Date:  2001-10       Impact factor: 4.272

6.  Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.

Authors:  C Spilianakis; J Papamatheakis; A Kretsovali
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

7.  The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.

Authors:  J A Harton; E Zika; J P Ting
Journal:  J Biol Chem       Date:  2001-08-20       Impact factor: 5.157

8.  MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300.

Authors:  T J Sisk; T Gourley; S Roys; C H Chang
Journal:  J Immunol       Date:  2000-09-01       Impact factor: 5.422

9.  PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.

Authors:  C H Leung; W Lam; W J Zhuang; N S Wong; M S Yang; W F Fong
Journal:  Biochem Biophys Res Commun       Date:  2001-07-13       Impact factor: 3.575

10.  Class II major histocompatibility complex transactivator (CIITA) inhibits matrix metalloproteinase-9 gene expression.

Authors:  Susan Nozell; Zhendong Ma; Cynthia Wilson; Reesha Shah; Etty N Benveniste
Journal:  J Biol Chem       Date:  2004-07-07       Impact factor: 5.157
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  16 in total

1.  Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator (CIITA) transactivation and major histocompatibility class II expression.

Authors:  Kavita Purnanda Bhat; Agnieszka Dorota Truax; Susanna Fletcher Greer
Journal:  J Biol Chem       Date:  2010-06-10       Impact factor: 5.157

Review 2.  Regulation of major histocompatibility complex class II genes.

Authors:  Nancy M Choi; Parimal Majumder; Jeremy M Boss
Journal:  Curr Opin Immunol       Date:  2010-10-21       Impact factor: 7.486

3.  Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.

Authors:  Ping Li; Yuhao Zhao; Xiaoyan Wu; Minjie Xia; Mingming Fang; Yasumasa Iwasaki; Jiahao Sha; Qi Chen; Yong Xu; Aiguo Shen
Journal:  Nucleic Acids Res       Date:  2011-11-07       Impact factor: 16.971

4.  SIRT1 links CIITA deacetylation to MHC II activation.

Authors:  Xiaoyan Wu; Xiaocen Kong; Dewei Chen; He Li; Yuhao Zhao; Minjie Xia; Mingming Fang; Ping Li; Fei Fang; Lina Sun; Wenfang Tian; Huihui Xu; Yuyu Yang; Xiaohong Qi; Yuqi Gao; Jiahao Sha; Qi Chen; Yong Xu
Journal:  Nucleic Acids Res       Date:  2011-09-02       Impact factor: 16.971

5.  CIITA and Its Dual Roles in MHC Gene Transcription.

Authors:  Ballachanda N Devaiah; Dinah S Singer
Journal:  Front Immunol       Date:  2013-12-20       Impact factor: 7.561

6.  The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination.

Authors:  Julie E Morgan; Ronald L Shanderson; Nathaniel H Boyd; Ercan Cacan; Susanna F Greer
Journal:  Biosci Rep       Date:  2015-06-19       Impact factor: 3.840

7.  PML promotes MHC class II gene expression by stabilizing the class II transactivator.

Authors:  Tobias Ulbricht; Mohammad Alzrigat; Almut Horch; Nina Reuter; Anna von Mikecz; Viktor Steimle; Eberhard Schmitt; Oliver H Krämer; Thomas Stamminger; Peter Hemmerich
Journal:  J Cell Biol       Date:  2012-09-24       Impact factor: 10.539

8.  Class II transactivator (CIITA) mediates transcriptional repression of pdk4 gene by interacting with hypermethylated in cancer 1 (HIC1).

Authors:  Mingming Fang; Ping Li; Xiaoyan Wu; Yong Xu
Journal:  J Biomed Res       Date:  2015-06-30

9.  The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators.

Authors:  Greta Forlani; Rawan Abdallah; Roberto S Accolla; Giovanna Tosi
Journal:  Front Microbiol       Date:  2013-08-22       Impact factor: 5.640

Review 10.  Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis.

Authors:  Markella Ponticos; Barbara D Smith
Journal:  J Biomed Res       Date:  2013-09-20
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