Literature DB >> 1971968

Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo.

C G Shin1, J M Strayer, M A Wani, R M Snapka.   

Abstract

Caffeine was found to inhibit both type I and type II topoisomerases in vivo as judged by its effects on replicating simian virus 40 (SV40) chromosomes. The study was facilitated by the use of a rapid filter assay for the detection and characterization of topoisomerase inhibitors. The assay, which requires neither purified enzymes nor substrates, was able to identify both antagonists and poisons of type I and type II topoisomerases.

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Year:  1990        PMID： 1971968     DOI： 10.1002/tcm.1770100106

Source DB:  PubMed          Journal:  Teratog Carcinog Mutagen        ISSN： 0270-3211


  8 in total

1.  Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.

Authors:  J A Ross; J D Potter; G H Reaman; T W Pendergrass; L L Robison
Journal:  Cancer Causes Control       Date:  1996-11       Impact factor: 2.506

2.  Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells.

Authors:  Samir A Salama; Hany H Arab; Hany A Omar; Ibrahim A Maghrabi; Robert M Snapka
Journal:  Inflammation       Date:  2014-06       Impact factor: 4.092

3.  XK469, a selective topoisomerase IIbeta poison.

Authors:  H Gao; K C Huang; E F Yamasaki; K K Chan; L Chohan; R M Snapka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

4.  Aphidicolin-induced topological and recombinational events in simian virus 40.

Authors:  R M Snapka; C G Shin; P A Permana; J Strayer
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

5.  Topoisomerase IV is a target of quinolones in Escherichia coli.

Authors:  A B Khodursky; E L Zechiedrich; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

6.  Synergistic and additive combinations of several antitumor drugs and other agents with the potent alkylating agent adozelesin.

Authors:  K S Smith; B A Folz; E G Adams; B K Bhuyan
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

7.  Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.

Authors:  A L Ellis; B Nowak; W Plunkett; L A Zwelling
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

8.  Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.

Authors:  Slawomir Kumala; Krzysztof Fujarewicz; Dheekollu Jayaraju; Joanna Rzeszowska-Wolny; Ronald Hancock
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240
  8 in total

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