BACKGROUND: Whether T-wave morphology descriptors on the 12-lead electrocardiogram (ECG) can predict the occurrence of life-threatening ventricular arrhythmia in patients with advanced congestive heart failure is unclear. METHODS: Standard 12-lead ECGs were photoscanned and digitized for analysis in 27 heart failure patients with ventricular tachycardia/ventricular fibrillation (VT/VF; study group), as well as in 54 age- and sex-matched heart failure patients without life-threatening ventricular arrhythmia as a control group. Novel T-wave morphology descriptors were compared. RESULTS: The results showed that the temporal descriptor, the lead dispersion (LD; 426.5 +/- 279.8 vs 189.0 +/- 125.7, P < 0.001), was significantly higher in the study than in the control group. The other T-wave morphology parameters, such as the T-wave morphology dispersion (45.7 +/- 20.1 vs 44.9 +/- 18.6), the total cosine between QRS and T wave (TCRT; -0.4 +/- 0.4 vs -0.5 +/- 0.3), and the normalized T-loop area (NTLA; 0.5 +/- 0.1 vs 0.4 +/- 0.1), were not significantly different between the two groups (all P value > 0.05). After an adjustment for other clinical variables, increased LD (odds ratio: 9.9, 95% confidence interval [CI]: 2.9-33.4, P < 0.001) or decreased NTLA (odds ratio: 0.4, 95% CI: 0.1-1.0, P =0.05) was associated with VT/VF. CONCLUSION: The novel T-wave morphology analysis may help in identifying heart failure patients at high risk for VT/VF.
BACKGROUND: Whether T-wave morphology descriptors on the 12-lead electrocardiogram (ECG) can predict the occurrence of life-threatening ventricular arrhythmia in patients with advanced congestive heart failure is unclear. METHODS: Standard 12-lead ECGs were photoscanned and digitized for analysis in 27 heart failurepatients with ventricular tachycardia/ventricular fibrillation (VT/VF; study group), as well as in 54 age- and sex-matched heart failurepatients without life-threatening ventricular arrhythmia as a control group. Novel T-wave morphology descriptors were compared. RESULTS: The results showed that the temporal descriptor, the lead dispersion (LD; 426.5 +/- 279.8 vs 189.0 +/- 125.7, P < 0.001), was significantly higher in the study than in the control group. The other T-wave morphology parameters, such as the T-wave morphology dispersion (45.7 +/- 20.1 vs 44.9 +/- 18.6), the total cosine between QRS and T wave (TCRT; -0.4 +/- 0.4 vs -0.5 +/- 0.3), and the normalized T-loop area (NTLA; 0.5 +/- 0.1 vs 0.4 +/- 0.1), were not significantly different between the two groups (all P value > 0.05). After an adjustment for other clinical variables, increased LD (odds ratio: 9.9, 95% confidence interval [CI]: 2.9-33.4, P < 0.001) or decreased NTLA (odds ratio: 0.4, 95% CI: 0.1-1.0, P =0.05) was associated with VT/VF. CONCLUSION: The novel T-wave morphology analysis may help in identifying heart failurepatients at high risk for VT/VF.
Authors: Gary Tse; Mengqi Gong; Cheuk Wai Wong; Cynthia Chan; Stamatis Georgopoulos; Yat Sun Chan; Bryan P Yan; Guangping Li; Paula Whittaker; Ana Ciobanu; Sadeq Ali-Hasan-Al-Saegh; Sunny H Wong; William K K Wu; George Bazoukis; Konstantinos Lampropoulos; Wing Tak Wong; Lap Ah Tse; Adrian M Baranchuk; Konstantinos P Letsas; Tong Liu Journal: Ann Noninvasive Electrocardiol Date: 2017-09-12 Impact factor: 1.468