| Literature DB >> 19719157 |
Ylva E Bergman1, Mark P Del Borgo, Romila D Gopalan, Sania Jalal, Sharon E Unabia, Marisa Ciampini, Daniel J Clayton, Jordan M Fletcher, Roger J Mulder, Jacqueline A Wilce, Marie-Isabel Aguilar, Patrick Perlmutter.
Abstract
The first synthesis of carbon-stapled beta(3)-peptides is reported. The precursor beta(3)-peptides, with O-allyl beta-serines located in an i/i+3 relationship, were prepared on solid phase. We show that efficient ring-closing metathesis (RCM) of these new beta(3)-peptides proceeds smoothly either in solution or on an appropriate solid support. All products were generated with high selectivity for the E-isomer.Entities:
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Year: 2009 PMID： 19719157 DOI： 10.1021/ol901803d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005