Literature DB >> 19717739

Neurofibromin homologs Ira1 and Ira2 affect glycerophosphoinositol production and transport in Saccharomyces cerevisiae.

Andrew C Bishop1, Beth A Surlow, Puneet Anand, Katherine Hofer, Matthew Henkel, Jana Patton-Vogt.   

Abstract

Saccharomyces cerevisiae produces extracellular glycerophosphoinositol through phospholipase-mediated turnover of phosphatidylinositol and transports glycerophosphoinositol into the cell upon nutrient limitation. A screening identified the RAS GTPase-activating proteins Ira1 and Ira2 as required for utilization of glycerophosphoinositol as the sole phosphate source, but the RAS/cyclic AMP pathway does not appear to be involved in the growth phenotype. Ira1 and Ira2 affect both the production and transport of glycerophosphoinositol.

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Year:  2009        PMID： 19717739      PMCID： PMC2772407          DOI： 10.1128/EC.00217-09

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  26 in total

Review 1.  Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms.

Authors:  Gerald Weeks; George B Spiegelman
Journal:  Cell Signal       Date:  2003-10       Impact factor: 4.315

2.  The regulated catabolism of endogenous and exogenous phosphatidylinositol by Saccharomyces cerevisiae leading to extracellular glycerophosphorylinositol and inositol.

Authors:  W W Angus; R L Lester
Journal:  J Biol Chem       Date:  1975-01-10       Impact factor: 5.157

Review 3.  Nutrient signals driving cell growth.

Authors:  Reinhard Dechant; Matthias Peter
Journal:  Curr Opin Cell Biol       Date:  2008-11-01       Impact factor: 8.382

4.  Functional homology of mammalian and yeast RAS genes.

Authors:  T Kataoka; S Powers; S Cameron; O Fasano; M Goldfarb; J Broach; M Wigler
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

5.  In yeast, RAS proteins are controlling elements of adenylate cyclase.

Authors:  T Toda; I Uno; T Ishikawa; S Powers; T Kataoka; D Broek; S Cameron; J Broach; K Matsumoto; M Wigler
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

6.  The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

Authors:  R Ballester; D Marchuk; M Boguski; A Saulino; R Letcher; M Wigler; F Collins
Journal:  Cell       Date:  1990-11-16       Impact factor: 41.582

7.  The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.

Authors:  G F Xu; B Lin; K Tanaka; D Dunn; D Wood; R Gesteland; R White; R Weiss; F Tamanoi
Journal:  Cell       Date:  1990-11-16       Impact factor: 41.582

8.  Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway.

Authors:  A M Buchberg; L S Cleveland; N A Jenkins; N G Copeland
Journal:  Nature       Date:  1990-09-20       Impact factor: 49.962

9.  IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

Authors:  K Tanaka; K Matsumoto; A Toh-E
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

10.  Glycerophosphoinositol, a novel phosphate source whose transport is regulated by multiple factors in Saccharomyces cerevisiae.

Authors:  Claudia Almaguer; Wei Cheng; Christi Nolder; Jana Patton-Vogt
Journal:  J Biol Chem       Date:  2004-05-15       Impact factor: 5.157
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  1 in total

1.  Control of nongenetic heterogeneity in growth rate and stress tolerance of Saccharomyces cerevisiae by cyclic AMP-regulated transcription factors.

Authors:  Shuang Li; Daniella M Giardina; Mark L Siegal
Journal:  PLoS Genet       Date:  2018-11-02       Impact factor: 5.917
  1 in total

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