OBJECTIVE: We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women. METHODS: A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used. RESULTS: There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort. CONCLUSION: Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women.
RCT Entities:
OBJECTIVE: We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women. METHODS: A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used. RESULTS: There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort. CONCLUSION: Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women.
Authors: B M Mercer; M Miodovnik; G R Thurnau; R L Goldenberg; A F Das; R D Ramsey; Y A Rabello; P J Meis; A H Moawad; J D Iams; J P Van Dorsten; R H Paul; S F Bottoms; G Merenstein; E A Thom; J M Roberts; D McNellis Journal: JAMA Date: 1997-09-24 Impact factor: 56.272
Authors: Brad D Thigpen; W Ashley Hood; Suneet Chauhan; Laura Bufkin; James Bofill; Everett Magann; John C Morrison Journal: Am J Obstet Gynecol Date: 2005-06 Impact factor: 8.661
Authors: L A Guay; P Musoke; T Fleming; D Bagenda; M Allen; C Nakabiito; J Sherman; P Bakaki; C Ducar; M Deseyve; L Emel; M Mirochnick; M G Fowler; L Mofenson; P Miotti; K Dransfield; D Bray; F Mmiro; J B Jackson Journal: Lancet Date: 1999-09-04 Impact factor: 79.321
Authors: William W Andrews; John C Hauth; Suzanne P Cliver; Karen Savage; Robert L Goldenberg Journal: Obstet Gynecol Date: 2003-06 Impact factor: 7.661
Authors: William W Andrews; Baha M Sibai; Elizabeth A Thom; Donald Dudley; J M Ernest; Donald McNellis; Kenneth J Leveno; Ronald Wapner; Atef Moawad; Mary J O'Sullivan; Steve N Caritis; Jay D Iams; Oded Langer; Menachem Miodovnik; Mitchell Dombrowski Journal: Obstet Gynecol Date: 2003-05 Impact factor: 7.661
Authors: Robert L Goldenberg; Anthony Mwatha; Jennifer S Read; Samuel Adeniyi-Jones; Moses Sinkala; Gernard Msmanga; Francis Martinson; Irving Hoffman; Wafaie Fawzi; Megan Valentine; Lynda Emel; Elizabeth Brown; Victor Mudenda; Taha E Taha Journal: Am J Obstet Gynecol Date: 2006-03 Impact factor: 8.661
Authors: Lisa M Bebell; Joseph Ngonzi; Mark J Siedner; Winnie R Muyindike; Bosco M Bwana; Laura E Riley; Yap Boum; David R Bangsberg; Ingrid V Bassett Journal: AIDS Care Date: 2018-02-16
Authors: Malene Plejdrup Hansen; Anna M Scott; Amanda McCullough; Sarah Thorning; Jeffrey K Aronson; Elaine M Beller; Paul P Glasziou; Tammy C Hoffmann; Justin Clark; Chris B Del Mar Journal: Cochrane Database Syst Rev Date: 2019-01-18
Authors: Tamil Kendall; Isabella Danel; Diane Cooper; Sophie Dilmitis; Angela Kaida; Athena P Kourtis; Ana Langer; Ilana Lapidos-Salaiz; Eva Lathrop; Allisyn C Moran; Hannah Sebitloane; Janet M Turan; D Heather Watts; Mary Nell Wegner Journal: J Acquir Immune Defic Syndr Date: 2014-12-01 Impact factor: 3.731