Literature DB >> 19716470

Fatty acid synthesis and PPARalpha hand in hand.

Nicolas Rotman1, Walter Wahli.   

Abstract

How can an ex-orphan be adopted? Is it possible to do so by attributing to it a key endogenous ligand that regulates its central functions? In the recent issue of Cell, Chakravarthy et al. attempted to answer this question by characterizing a new physiologically relevant ligand for the ex-orphan receptor peroxisome proliferator activated receptor alpha (PPARalpha).

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Year:  2009        PMID: 19716470     DOI: 10.1016/j.chembiol.2009.08.004

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  3 in total

Review 1.  PPAR-α as a key nutritional and environmental sensor for metabolic adaptation.

Authors:  Alejandra V Contreras; Nimbe Torres; Armando R Tovar
Journal:  Adv Nutr       Date:  2013-07-01       Impact factor: 8.701

2.  Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.

Authors:  Margaret Wu; Sheo B Singh; Jun Wang; Christine C Chung; Gino Salituro; Bindhu V Karanam; Sang Ho Lee; Maryann Powles; Kenneth P Ellsworth; Michael E Lassman; Corey Miller; Robert W Myers; Michael R Tota; Bei B Zhang; Cai Li
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-09       Impact factor: 11.205

3.  Targeting Nuclear Hormone Receptors: PPARα Agonists as Potential Disease-Modifying Drugs for Rheumatoid Arthritis.

Authors:  Ivan V Shirinsky; Valery S Shirinsky
Journal:  Int J Rheumatol       Date:  2011-06-21
  3 in total

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