| Literature DB >> 19716295 |
Yasushi Todoroki1, Hikaru Aoyama, Saori Hiramatsu, Minaho Shirakura, Hataitip Nimitkeatkai, Satoru Kondo, Kotomi Ueno, Masaharu Mizutani, Nobuhiro Hirai.
Abstract
We enlarged the uniconazole (UNI) molecule to find a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase, and synthesized various UNI derivatives that were substituted with hydrophilic and hydrophobic groups at the 4-chlorine of the phenyl group of UNI using click chemistry. Considering its potency in ABA 8'-hydroxylase inhibition, its small effect on seedling growth, and its ease of application, UT4, the UNI derivative containing the C4 alkyltriazole, was the best candidate for a highly selective inhibitor of ABA 8'-hydroxylase.Entities:
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Year: 2009 PMID： 19716295 DOI： 10.1016/j.bmcl.2009.07.137
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823