Literature DB >> 1971494

Interactions between the human monocytic leukaemia THP-1 cell line and Old and New World species of Leishmania.

B W Ogunkolade1, I Colomb-Valet, L Monjour, A Rhodes-Feuillette, J P Abita, D Frommel.   

Abstract

The human promyelocytic THP-1 cell line has been found to support the growth of Leishmania parasites. THP-1 cells, differentiated with retinoic acid, cease replication while remaining in suspension. 72 +/- 8% of THP-1 cells became infected after inoculation with promastigotes of several Old and New World Leishmania species. The resulting amastigotes (19 +/- 5 per infected cell) were easy to harvest, capable of reinfecting cultures of normal human cells and, in the case of L. major and L. infantum, caused specific lesions in BALB/c mice. This culture system should facilitate biochemical and immunological studies on amastigotes and be of use in screening anti-parasite drugs.

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Year:  1990        PMID： 1971494     DOI： 10.1016/0001-706x(90)90023-s

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  8 in total

1.  Flow cytometric screening for anti-leishmanials in a human macrophage cell line.

Authors:  Sanjay R Mehta; Xing-Quan Zhang; Roberto Badaro; Celsa Spina; John Day; Kwang-Poo Chang; Robert T Schooley
Journal:  Exp Parasitol       Date:  2010-06-09       Impact factor: 2.011

2.  Flow cytometric detection of Leishmania parasites in human monocyte-derived macrophages: application to antileishmanial-drug testing.

Authors:  C Di Giorgio; O Ridoux; F Delmas; N Azas; M Gasquet; P Timon-David
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

3.  In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis.

Authors:  Florence Delmas; Carole Di Giorgio; Maxime Robin; Nadine Azas; Monique Gasquet; Claire Detang; Muriel Costa; Pierre Timon-David; Jean-Pierre Galy
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

4.  In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum.

Authors:  Carole Di Giorgio; Florence Delmas; Nathalie Filloux; Maxime Robin; Laetitia Seferian; Nadine Azas; Monique Gasquet; Muriel Costa; Pierre Timon-David; Jean-Pierre Galy
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

5.  A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani.

Authors:  Diana Tegazzini; Rosario Díaz; Fernando Aguilar; Imanol Peña; Jesús L Presa; Vanessa Yardley; Julio J Martin; Jose M Coteron; Simon L Croft; Juan Cantizani
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

6.  A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit.

Authors:  Geraldine De Muylder; Kenny K H Ang; Steven Chen; Michelle R Arkin; Juan C Engel; James H McKerrow
Journal:  PLoS Negl Trop Dis       Date:  2011-07-19

7.  Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target.

Authors:  Shweta Raj; Gundappa Saha; Santanu Sasidharan; Vikash Kumar Dubey; Prakash Saudagar
Journal:  Sci Rep       Date:  2019-11-07       Impact factor: 4.379

8.  Novel dual-fluorescent flow cytometric approach for quantification of macrophages infected with Leishmania infantum parasites.

Authors:  Zeynep Islek; Mehmet Hikmet Ucisik; Fikrettin Sahin
Journal:  Parasitology       Date:  2021-09-07       Impact factor: 3.234
  8 in total

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