PURPOSE: Four-dimensional (4D) radiotherapy, in particular respiration gating for the treatment of lung tumors, is gaining popularity. Its utility for other sites, however, has not been investigated fully. The purpose of this study was to see whether 4D therapy is feasible for liver tumors. MATERIAL AND METHODS: Six patients (five with hepatomas and one with metastatic liver tumor) had a fiducial, gold marker 1.5 mm in diameter implanted in the vicinity of their liver tumors. The inner and external (i.e., upper abdominal wall) respiratory movements were simultaneously recorded using a real-time tumor-tracking radiotherapy system and respiration monitor equipment applied to the mid to upper abdomen. RESULTS: The fluctuations from the baseline position of liver tumors were small; the mean absolute value was 3.92 +/- 1.94 mm. The mean right-left, anteroposterior, and craniocaudal total movements were 4.19 +/- 2.46, 7.23 +/- 2.96, and 15.98 +/- 6.02 mm, respectively. The phase shift was negligible. CONCLUSION: Liver tumors may be suitable for respiration-gated radiotherapy, and they may become curable with 4D radiotherapy.
PURPOSE: Four-dimensional (4D) radiotherapy, in particular respiration gating for the treatment of lung tumors, is gaining popularity. Its utility for other sites, however, has not been investigated fully. The purpose of this study was to see whether 4D therapy is feasible for liver tumors. MATERIAL AND METHODS: Six patients (five with hepatomas and one with metastatic liver tumor) had a fiducial, gold marker 1.5 mm in diameter implanted in the vicinity of their liver tumors. The inner and external (i.e., upper abdominal wall) respiratory movements were simultaneously recorded using a real-time tumor-tracking radiotherapy system and respiration monitor equipment applied to the mid to upper abdomen. RESULTS: The fluctuations from the baseline position of liver tumors were small; the mean absolute value was 3.92 +/- 1.94 mm. The mean right-left, anteroposterior, and craniocaudal total movements were 4.19 +/- 2.46, 7.23 +/- 2.96, and 15.98 +/- 6.02 mm, respectively. The phase shift was negligible. CONCLUSION:Liver tumors may be suitable for respiration-gated radiotherapy, and they may become curable with 4D radiotherapy.
Authors: Femke O B Spoelstra; John R van Sörnsen de Koste; Johan P Cuijpers; Frank J Lagerwaard; Ben J Slotman; Suresh Senan Journal: Radiother Oncol Date: 2008-03-11 Impact factor: 6.280
Authors: Jenghwa Chang; Gig S Mageras; Ellen Yorke; Fernando De Arruda; Jussi Sillanpaa; Kenneth E Rosenzweig; Agung Hertanto; Hai Pham; Edward Seppi; Alex Pevsner; C Clifton Ling; Howard Amols Journal: Int J Radiat Oncol Biol Phys Date: 2007-04-01 Impact factor: 7.038
Authors: Sunil Krishnan; Tina Marie Briere; Lei Dong; Ravi Murthy; Chaan Ng; Peter Balter; Radhe Mohan; Michael T Gillin; A Sam Beddar Journal: Med Phys Date: 2007-12 Impact factor: 4.071