INTRODUCTION: Many studies have demonstrated the prevalence of vitamin D insufficiency in the older population. OBJECTIVE: This study sought to determine whether supplementation with intramuscular vitamin D improved 25OH vitamin D levels significantly. SUBJECTS:Ninety female inpatients aged over 65 years were assigned to receive 300,000 IU of intramuscular vitamin D3 (cholecalciferol) or no intervention. METHODS:Baseline 25OH vitamin D and intact parathyroid hormone (iPTH) levels were taken and repeated 3 months after supplementation. RESULTS: Patients who received treatment showed a significant improvement in 25OH vitamin D levels, from 25.5 to 81 nmol/L with 11% remaining deficient. No patient became hypercalcaemic after treatment. CONCLUSIONS: Vitamin D deficiency is common throughout all age groups in the Irish population and particularly the older female population who have increased risk of osteoporosis and fractures. Intramuscular vitamin D significantly improves 25OH vitamin D levels compared to no treatment and may combat non-compliance with oral medication.
RCT Entities:
INTRODUCTION: Many studies have demonstrated the prevalence of vitamin Dinsufficiency in the older population. OBJECTIVE: This study sought to determine whether supplementation with intramuscular vitamin D improved 25OH vitamin D levels significantly. SUBJECTS: Ninety female inpatients aged over 65 years were assigned to receive 300,000 IU of intramuscular vitamin D3 (cholecalciferol) or no intervention. METHODS: Baseline 25OH vitamin D and intact parathyroid hormone (iPTH) levels were taken and repeated 3 months after supplementation. RESULTS:Patients who received treatment showed a significant improvement in 25OH vitamin D levels, from 25.5 to 81 nmol/L with 11% remaining deficient. No patient became hypercalcaemic after treatment. CONCLUSIONS:Vitamin D deficiency is common throughout all age groups in the Irish population and particularly the older female population who have increased risk of osteoporosis and fractures. Intramuscular vitamin D significantly improves 25OH vitamin D levels compared to no treatment and may combat non-compliance with oral medication.
Authors: M S Stein; J D Wark; S C Scherer; S L Walton; P Chick; M Di Carlantonio; J D Zajac; L Flicker Journal: J Am Geriatr Soc Date: 1999-10 Impact factor: 5.562
Authors: A M Grant; A Avenell; M K Campbell; A M McDonald; G S MacLennan; G C McPherson; F H Anderson; C Cooper; R M Francis; C Donaldson; W J Gillespie; C M Robinson; D J Torgerson; W A Wallace Journal: Lancet Date: 2005 May 7-13 Impact factor: 79.321
Authors: Daniel H Solomon; Jerry Avorn; Jeffrey N Katz; Joel S Finkelstein; Marilyn Arnold; Jennifer M Polinski; M Alan Brookhart Journal: Arch Intern Med Date: 2005-11-14