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Literature DB >> 1971420

Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.

E Di Marco¹, J H Pierce, C L Knicley, P P Di Fiore.

Abstract

While the normal human erbB-2 gene is potently transforming when overexpressed in NIH 3T3 cells, its rat homolog, the neu gene, seems to acquire transforming properties only upon alteration of its coding sequence. In this study, we compared the effects of different levels of expression of normal erbB-2 and neu in NIH 3T3 cells. Our results revealed that the normal rat neu gene acts as a potent oncogene when sufficiently overexpressed in NIH 3T3 cells.

Entities: Gene Species

Mesh：

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Year: 1990 PMID： 1971420 PMCID： PMC360691 DOI： 10.1128/mcb.10.6.3247-3252.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

27 in total

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Authors: P P Di Fiore; O Segatto; F Lonardo; F Fazioli; J H Pierce; S A Aaronson
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

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Authors: L C Padhy; C Shih; D Cowing; R Finkelstein; R A Weinberg
Journal: Cell Date: 1982-04 Impact factor: 41.582

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Authors: R C Mulligan; P Berg
Journal: Proc Natl Acad Sci U S A Date: 1981-04 Impact factor: 11.205

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Authors: C R King; M H Kraus; S A Aaronson
Journal: Science Date: 1985-09-06 Impact factor: 47.728

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Authors: K Semba; N Kamata; K Toyoshima; T Yamamoto
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

9. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Authors: L Coussens; T L Yang-Feng; Y C Liao; E Chen; A Gray; J McGrath; P H Seeburg; T A Libermann; J Schlessinger; U Francke
Journal: Science Date: 1985-12-06 Impact factor: 47.728

10. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts.

Authors: C Shih; L C Padhy; M Murray; R A Weinberg
Journal: Nature Date: 1981-03-19 Impact factor: 49.962

22 in total

1. Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.

Authors: L Lehtola; M Nistér; E Hölttä; B Westermark; K Alitalo
Journal: Cell Regul Date: 1991-08

2. Identification and characterization of a novel enhancer for the rat neu promoter.

Authors: D H Yan; M C Hung
Journal: Mol Cell Biol Date: 1991-04 Impact factor: 4.272

3. Protein quantification from complex protein mixtures using a proteomics methodology with single-cell resolution.

Authors: H T Zhang; J E Kacharmina; K Miyashiro; M I Greene; J Eberwine
Journal: Proc Natl Acad Sci U S A Date: 2001-04-24 Impact factor: 11.205

4. Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice.

Authors: Laura Masuelli; Laura Marzocchella; Chiara Focaccetti; Florigio Lista; Alessandra Nardi; Antonio Scardino; Maurizio Mattei; Mario Turriziani; Mauro Modesti; Guido Forni; Jeffrey Schlom; Andrea Modesti; Roberto Bei
Journal: Cancer Immunol Immunother Date: 2010-04-04 Impact factor: 6.968

Review 5. Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu.

Authors: Elizabeth A Fry; Pankaj Taneja; Kazushi Inoue
Journal: Int J Cancer Date: 2016-09-12 Impact factor: 7.396

6. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

Authors: C T Guy; M A Webster; M Schaller; T J Parsons; R D Cardiff; W J Muller
Journal: Proc Natl Acad Sci U S A Date: 1992-11-15 Impact factor: 11.205

7. Selection of potentially metastatic subpopulations expressing c-erbB-2 from breast cancer tissue by use of an extravasation model.

Authors: A Roetger; A Merschjann; T Dittmar; C Jackisch; A Barnekow; B Brandt
Journal: Am J Pathol Date: 1998-12 Impact factor: 4.307

Review 8. Calcium-mediated signal transduction: biology, biochemistry, and therapy.

Authors: K Cole; E Kohn
Journal: Cancer Metastasis Rev Date: 1994-03 Impact factor: 9.264

9. Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.

Authors: S M Jong; C S Zong; T Dorai; L H Wang
Journal: J Virol Date: 1992-08 Impact factor: 5.103

10. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

Authors: J M Bosher; T Williams; H C Hurst
Journal: Proc Natl Acad Sci U S A Date: 1995-01-31 Impact factor: 11.205