OBJECTIVE: The ReSTAGE collaboration evaluated four menstrual markers of entry to late-stage menopausal transition. The aim of this study was to assess the additional usefulness of "persistence" in relation to a clinically accessible menstrual marker of late menopausal transition, taking age into account. METHODS: In this study, a secondary analysis of menstrual calendar data in two ReSTAGE-collaborating studies with comparatively low age at beginning of menstrual calendar observation was performed. RESULTS: Sixty days of amenorrhea is as useful for predicting time to the final menstrual period as the currently accepted 90-day marker for women older than 45 years. For those aged between 40 and 44 years, recurrence of the 60-day marker within the next 10 cycles is a better indicator than a single occurrence of the 60-day marker or the 90-day marker. CONCLUSIONS: Sixty-day amenorrhea is as reliable a marker of late menopausal transition as the traditional 90-day marker for women older than 45 years. For those aged 40 to 44 years, keeping menstrual records to check for a recurrence of the 60-day marker will be useful.
OBJECTIVE: The ReSTAGE collaboration evaluated four menstrual markers of entry to late-stage menopausal transition. The aim of this study was to assess the additional usefulness of "persistence" in relation to a clinically accessible menstrual marker of late menopausal transition, taking age into account. METHODS: In this study, a secondary analysis of menstrual calendar data in two ReSTAGE-collaborating studies with comparatively low age at beginning of menstrual calendar observation was performed. RESULTS: Sixty days of amenorrhea is as useful for predicting time to the final menstrual period as the currently accepted 90-day marker for women older than 45 years. For those aged between 40 and 44 years, recurrence of the 60-day marker within the next 10 cycles is a better indicator than a single occurrence of the 60-day marker or the 90-day marker. CONCLUSIONS: Sixty-day amenorrhea is as reliable a marker of late menopausal transition as the traditional 90-day marker for women older than 45 years. For those aged 40 to 44 years, keeping menstrual records to check for a recurrence of the 60-day marker will be useful.
Authors: John F Randolph; Sybil Crawford; Lorraine Dennerstein; Kevin Cain; Siobán D Harlow; Roderick Little; Ellen S Mitchell; Bin Nan; John Taffe; Matheos Yosef Journal: J Clin Endocrinol Metab Date: 2006-05-23 Impact factor: 5.958
Authors: Siobán D Harlow; Kevin Cain; Sybil Crawford; Lorraine Dennerstein; Roderick Little; Ellen S Mitchell; Bin Nan; John F Randolph; John Taffe; Matheos Yosef Journal: J Clin Endocrinol Metab Date: 2006-06-13 Impact factor: 5.958
Authors: Siobán D Harlow; Ellen S Mitchell; Sybil Crawford; Bin Nan; Roderick Little; John Taffe Journal: Fertil Steril Date: 2007-08-06 Impact factor: 7.329
Authors: Kevin C Cain; Siobán D Harlow; Roderick J Little; Bin Nan; Matheos Yosef; John R Taffe; Michael R Elliott Journal: Am J Epidemiol Date: 2011-03-21 Impact factor: 4.897
Authors: Siobán D Harlow; Margery Gass; Janet E Hall; Roger Lobo; Pauline Maki; Robert W Rebar; Sherry Sherman; Patrick M Sluss; Tobie J de Villiers Journal: Climacteric Date: 2012-02-16 Impact factor: 3.005