PURPOSE OF REVIEW: The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting. RECENT FINDINGS: Although the search for the cachectic factor(s) started a long time ago, and although many scientific and economic efforts have been devoted to its discovery, we are still a long way from knowing the whole truth. In this review we describe recent findings about the tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, TWEAK and myostatin actions in cancer cachexia models. SUMMARY: The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators (mainly cytokines) involved in cancer cachexia since they may represent targets for future promising clinical investigations.
PURPOSE OF REVIEW: The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting. RECENT FINDINGS: Although the search for the cachectic factor(s) started a long time ago, and although many scientific and economic efforts have been devoted to its discovery, we are still a long way from knowing the whole truth. In this review we describe recent findings about the tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, TWEAK and myostatin actions in cancer cachexia models. SUMMARY: The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators (mainly cytokines) involved in cancer cachexia since they may represent targets for future promising clinical investigations.
Authors: Tanios Bekaii-Saab; Mitch A Phelps; Xiaobai Li; Motoyasu Saji; Laura Goff; John Sae Wook Kauh; Bert H O'Neil; Stephanie Balsom; Catherine Balint; Ryan Liersemann; Vasily V Vasko; Mark Bloomston; William Marsh; L Austin Doyle; Gilian Ellison; Michael Grever; Matthew D Ringel; Miguel A Villalona-Calero Journal: J Clin Oncol Date: 2011-04-25 Impact factor: 44.544
Authors: Takuo Yamaki; Chia-Ling Wu; Michael Gustin; Jamie Lim; Robert W Jackman; Susan C Kandarian Journal: Am J Physiol Cell Physiol Date: 2012-05-16 Impact factor: 4.249
Authors: Erin E Talbert; Jennifer Yang; Thomas A Mace; Matthew R Farren; Alton B Farris; Gregory S Young; Omar Elnaggar; Zheng Che; Cynthia D Timmers; Priyani Rajasekera; Jennifer M Maskarinec; Mark Bloomston; Tanios Bekaii-Saab; Denis C Guttridge; Gregory B Lesinski Journal: Mol Cancer Ther Date: 2016-11-03 Impact factor: 6.261
Authors: Lu Miao; Aaron K Holley; Yanming Zhao; William H St Clair; Daret K St Clair Journal: Antioxid Redox Signal Date: 2014-01-22 Impact factor: 8.401