| Literature DB >> 1971320 |
Abstract
The effect of the progesterone antagonist mifepristone on the cervix was investigated in two randomised double-blind placebo-controlled trials, the first in 30 women undergoing first trimester surgical termination of pregnancy and the second in 30 non-pregnant premenopausal women. 600 mg mifepristone, given orally 48 h before surgery, increased the mean preoperative cervical dilatation in both pregnant and non-pregnant treatment groups and also reduced the force required to dilate the pregnant and non-pregnant cervix.Entities:
Keywords: Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Biology; Cervical Dilatation; Cervical Effects; Cervix; Comparative Studies; Endocrine System; Family Planning; Fertility Control, Postconception; Genitalia; Genitalia, Female; Hormone Antagonists; Hormones; Physiology; Research Methodology; Ru-486--pharmacodynamics; Ru-486--side effects; Ru-486--therapeutic use; Studies; Treatment; Urogenital System; Uterus
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Year: 1990 PMID： 1971320 DOI： 10.1016/0140-6736(90)91303-r
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321