Literature DB >> 19713035

Halofuginone enhances the radiation sensitivity of human tumor cell lines.

John A Cook1, Rajani Choudhuri, William Degraff, Janet Gamson, James B Mitchell.   

Abstract

Transforming growth factor beta (TGF-beta) is implicated in radiation-induced fibrosis of normal tissues in patients receiving radiotherapy. Inhibiting the TGF-beta signaling pathway by various means has been shown to reduce radiation-induced fibrosis in pre-clinical studies. The present study evaluated the effects of interfering with the TGF-beta signaling pathway on the radiosensitivity of selected human tumor cell lines using the plant-derived alkaloid, halofuginone. Halofuginone treatment inhibited cell growth, halted cell cycle progression, decreased radiation-induced DNA damage repair, and decreased TGF-beta receptor II protein levels, leading to increased cellular radiosensitization. These data further support the goal of manipulating the TGF-beta pathway to achieve a positive increase in the therapeutic gain in clinical radiotherapy. Published by Elsevier Ireland Ltd.

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Year:  2009        PMID： 19713035      PMCID： PMC2835928          DOI： 10.1016/j.canlet.2009.08.009

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  35 in total

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4.  Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

Authors:  Sandhya Xavier; Ester Piek; Makiko Fujii; Delphine Javelaud; Alain Mauviel; Kathy C Flanders; Ayelet M Samuni; Angelina Felici; Michael Reiss; Shai Yarkoni; Anastasia Sowers; James B Mitchell; Anita B Roberts; Angelo Russo
Journal:  J Biol Chem       Date:  2004-01-19       Impact factor: 5.157

5.  Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone.

Authors:  A Nagler; M Ohana; O Shibolet; M Y Shapira; R Alper; I Vlodavsky; M Pines; Y Ilan
Journal:  Eur J Cancer       Date:  2004-06       Impact factor: 9.162

6.  Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

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Journal:  Mol Cancer Ther       Date:  2009-01       Impact factor: 6.261

7.  Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.

Authors:  Mitchell S Anscher; Bradley Thrasher; Larisa Zgonjanin; Zahid N Rabbani; Michael J Corbley; Kai Fu; Lihong Sun; Wen-Cherng Lee; Leona E Ling; Zeljko Vujaskovic
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8.  Halofuginone: an inhibitor of collagen type I synthesis.

Authors:  I Granot; O Halevy; S Hurwitz; M Pines
Journal:  Biochim Biophys Acta       Date:  1993-02-13

9.  Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats.

Authors:  Zahid N Rabbani; Mitchell S Anscher; Xiuwu Zhang; Liguang Chen; Thaddeus V Samulski; Chuan-Yuan Li; Zeljko Vujaskovic
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Review 10.  New rationales for using TGFbeta inhibitors in radiotherapy.

Authors:  Kumari L Andarawewa; Jenny Paupert; Anupama Pal; Mary Helen Barcellos-Hoff
Journal:  Int J Radiat Biol       Date:  2007 Nov-Dec       Impact factor: 2.694
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Review 2.  Targeting inflammatory pathways for tumor radiosensitization.

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3.  TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

Authors:  Fanny Bouquet; Anupama Pal; Karsten A Pilones; Sandra Demaria; Byron Hann; Rosemary J Akhurst; Jim S Babb; Scott M Lonning; J Keith DeWyngaert; Silvia C Formenti; Mary Helen Barcellos-Hoff
Journal:  Clin Cancer Res       Date:  2011-10-25       Impact factor: 12.531

Review 4.  Mechanisms of Normal Tissue Injury From Irradiation.

Authors:  Deborah E Citrin; James B Mitchell
Journal:  Semin Radiat Oncol       Date:  2017-10       Impact factor: 5.934

5.  Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.

Authors:  Suntaek Hong; Hye-Youn Kim; Jooyoung Kim; Huyen Trang Ha; Young-Mi Kim; Eunjin Bae; Tae Hyung Kim; Kang Choon Lee; Seong-Jin Kim
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6.  Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model.

Authors:  Faezeh Koohestani; Wenan Qiang; Amy L MacNeill; Stacy A Druschitz; Vanida A Serna; Malavika Adur; Takeshi Kurita; Romana A Nowak
Journal:  Hum Reprod       Date:  2016-04-29       Impact factor: 6.918

7.  Involvement of 5-Serotonin and Substance p Pathways in Dichroa Alkali Salt-Induced Acute Pica in Rats.

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8.  A Novel Synthesis of the Efficient Anti-Coccidial Drug Halofuginone Hydrobromide.

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Journal:  Molecules       Date:  2017-06-30       Impact factor: 4.411

Review 9.  Targeting the Integrated Stress Response in Cancer Therapy.

Authors:  Xiaobing Tian; Shengliang Zhang; Lanlan Zhou; Attila A Seyhan; Liz Hernandez Borrero; Yiqun Zhang; Wafik S El-Deiry
Journal:  Front Pharmacol       Date:  2021-09-24       Impact factor: 5.810

10.  Inhibition of TGF-β signaling with halofuginone can enhance the antitumor effect of irradiation in Lewis lung cancer.

Authors:  Runlong Lin; Shuai Yi; Linlin Gong; Weishuai Liu; Peng Wang; Ningbo Liu; Lujun Zhao; Ping Wang
Journal:  Onco Targets Ther       Date:  2015-12-02       Impact factor: 4.147
  10 in total

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