I Szollosi1, S J King, J W Wilson, M T Naughton. 1. Department of Allergy Immunology and Respiratory Medicine, Alfred Hospital, Department of Medicine and Nutrition, Monash University, Melbourne, Victoria, Australia.
Abstract
BACKGROUND: Whether autonomic dysfunction contributes to tachycardia in cystic fibrosis (CF) is unknown. METHODS: Heart rate variability (HRV) was assessed to determine high frequency power and the low/high frequency power ratio (HF, LF/HF) as markers of vagal and sympathovagal balance, respectively, under spontaneous and controlled breathing (15 breaths per minute (bpm)) conditions in 17 CF and 17 healthy control subjects. RESULTS: Under spontaneously breathing conditions, the CF group was tachycardic (75.4 ± 11.2 vs 60.2 ± 9.0 br/min P < 0.001) and tachypnoeic (22.6 ± 5.8 vs 13.6 ± 4.1 br/min, P= 0.001) compared with controls. No significant difference in HRV was observed between groups during spontaneous or controlled breathing. Coexistent diabetes mellitus and β(2) agonist use were not associated with altered autonomic control. During controlled breathing, the CF group showed a negative correlation between forced expiratory volume in 1 s (FEV(1)) % predicted and HF power (P= 0.013, r=-0.59) and a positive correlation between FEV(1) % predicted and LF/HF ratio (P= 0.002, r= 0.69) suggesting an exaggerated normal vagal response. CONCLUSION: CF patients have normal autonomic function.
BACKGROUND: Whether autonomic dysfunction contributes to tachycardia in cystic fibrosis (CF) is unknown. METHODS: Heart rate variability (HRV) was assessed to determine high frequency power and the low/high frequency power ratio (HF, LF/HF) as markers of vagal and sympathovagal balance, respectively, under spontaneous and controlled breathing (15 breaths per minute (bpm)) conditions in 17 CF and 17 healthy control subjects. RESULTS: Under spontaneously breathing conditions, the CF group was tachycardic (75.4 ± 11.2 vs 60.2 ± 9.0 br/min P < 0.001) and tachypnoeic (22.6 ± 5.8 vs 13.6 ± 4.1 br/min, P= 0.001) compared with controls. No significant difference in HRV was observed between groups during spontaneous or controlled breathing. Coexistent diabetes mellitus and β(2) agonist use were not associated with altered autonomic control. During controlled breathing, the CF group showed a negative correlation between forced expiratory volume in 1 s (FEV(1)) % predicted and HF power (P= 0.013, r=-0.59) and a positive correlation between FEV(1) % predicted and LF/HF ratio (P= 0.002, r= 0.69) suggesting an exaggerated normal vagal response. CONCLUSION: CF patients have normal autonomic function.
Authors: Pitiguara de Freitas Coelho; Roberta Ribeiro Batista Barbosa; Rodrigo Dos Santos Lugao; Fernanda Mayrink Gonçalves Liberato; Pâmela Reis Vidal; Roberta de Cássia Nunes Cruz Melotti; Márcio Vinícius Fagundes Donadio Journal: Hong Kong Physiother J Date: 2021-06-11
Authors: Eleonora Tobaldini; Gabriel D Rodrigues; Giorgio Mantoan; Alice Monti; Giulia Coti Zelati; Camilla Cirelli; Paolo Tarsia; Letizia Corinna Morlacchi; Valeria Rossetti; Ilaria Righi; Mario Nosotti; Pedro Paulo da S Soares; Nicola Montano; Stefano Aliberti; Francesco Blasi Journal: J Clin Med Date: 2020-04-17 Impact factor: 4.241
Authors: Rodrigo Dos Santos Lugao; Roberta Ribeiro Batista Barbosa; Pitiguara de Freitas Coelho; Fernanda Mayrink Gonçalves Liberato; Pâmela Reis Vidal; Roberta Barcellos Couto Olimpio de Carvalho; Roberta de Cássia Nunes Cruz Melotti; Márcio Vinícius Fagundes Donadio Journal: Rev Paul Pediatr Date: 2021-09-01