INTRODUCTION: Gastric cancer is still one of the most common fatal types of cancer in the world. The abnormalities in purine metabolism are a characteristic feature of many human tumors. Little is known about the correlation between the activities of key enzymes of purine nucleotide pathway and some clinical indicators of gastric cancer invasiveness and aggressiveness. METHOD: Seventeen (11 men, 6 women) patients with gastric cancer were admitted to the hospital. The activities of Adenosine deaminase (ADA) and 5'-nucleotidase (5'NT) in their cancerous and non-cancerous tissues were measured. RESULTS: 5'NT activities were significantly higher in cancerous tissues than in non-cancerous tissues. CONCLUSION: 5'NT activities increased in gastric cancer tissues but had no association with clinicopathologic findings (Tab. 2, Ref. 9). Full Text (Free, PDF) www.bmj.sk.
INTRODUCTION:Gastric cancer is still one of the most common fatal types of cancer in the world. The abnormalities in purine metabolism are a characteristic feature of many humantumors. Little is known about the correlation between the activities of key enzymes of purine nucleotide pathway and some clinical indicators of gastric cancer invasiveness and aggressiveness. METHOD: Seventeen (11 men, 6 women) patients with gastric cancer were admitted to the hospital. The activities of Adenosine deaminase (ADA) and 5'-nucleotidase (5'NT) in their cancerous and non-cancerous tissues were measured. RESULTS: 5'NT activities were significantly higher in cancerous tissues than in non-cancerous tissues. CONCLUSION: 5'NT activities increased in gastric cancer tissues but had no association with clinicopathologic findings (Tab. 2, Ref. 9). Full Text (Free, PDF) www.bmj.sk.
Authors: Mahmut Sunnetcioglu; Sevdegul Karadas; Mehmet Aslan; Mehmet Resat Ceylan; Halit Demir; Mehmet Resit Oncu; Mustafa Kasım Karahocagil; Aysel Sunnetcioglu; Cenk Aypak Journal: Med Sci Monit Date: 2014-07-06