BACKGROUND: Limited information exists regarding the association between subjective well-being (SWB) and systolic blood pressure (SBP) among hypertensive patients with coronary artery disease (CAD). HYPOTHESIS: We tested the hypothesis that there is an association between SBP and SWB. METHODS: We studied 22,576 hypertensive CAD patients > or = 50 years old in the INternationalVErapamil SR-Trandolapril Study (INVEST), a randomized, blinded-endpoint trial of antihypertensive therapyin stable CAD patients. At each study visit, patients rated their SWB in the previous 4 weeks as "excellent," "good," "fair," or "poor" prior to SBP recordings. The outcome measure was SWB of "fair" or "poor." A longitudinal analysis using generalized estimating equations was performed to assess the association between SBP and odds of reporting fair/poor SWB, controlling for baseline SWB of fair/poor and angina reported during the study. RESULTS: Patients with higher SBP had higher odds of reporting fair/poor SWB. Specifically, compared with patients with SBP of < or = 120, patients with SBP 140-150 > 150 - < or = 160 and > 160 had about 90% and 2.5 times greater odds of feeling fair/poor, respectively (adjusted odds ratio [OR]: 1.5990, 95% confidence interval [CI]: 1.81-2.00 and adjusted OR: 2.53, 95% CI: 2.41-2.66). Those who reported angina in the 4 wks prior to a protocol visit had 2.2 times greater odds of reporting fair/poor SWB (adjusted OR: 2.2, 95% CI: 2.13-2.27). Female gender, black race, history of smoking, diabetes, myocardial infarction, stroke, and cancer also increased the odds of reporting fair/poor SWB. CONCLUSIONS: Among hypertensive CAD patients, higher on-treatment SBP is associated with greater odds of fair/poor SWB during follow-up.
RCT Entities:
BACKGROUND: Limited information exists regarding the association between subjective well-being (SWB) and systolic blood pressure (SBP) among hypertensivepatients with coronary artery disease (CAD). HYPOTHESIS: We tested the hypothesis that there is an association between SBP and SWB. METHODS: We studied 22,576 hypertensive CADpatients > or = 50 years old in the INternational VErapamil SR-Trandolapril Study (INVEST), a randomized, blinded-endpoint trial of antihypertensive therapy in stable CAD patients. At each study visit, patients rated their SWB in the previous 4 weeks as "excellent," "good," "fair," or "poor" prior to SBP recordings. The outcome measure was SWB of "fair" or "poor." A longitudinal analysis using generalized estimating equations was performed to assess the association between SBP and odds of reporting fair/poor SWB, controlling for baseline SWB of fair/poor and angina reported during the study. RESULTS:Patients with higher SBP had higher odds of reporting fair/poor SWB. Specifically, compared with patients with SBP of < or = 120, patients with SBP 140-150 > 150 - < or = 160 and > 160 had about 90% and 2.5 times greater odds of feeling fair/poor, respectively (adjusted odds ratio [OR]: 1.5990, 95% confidence interval [CI]: 1.81-2.00 and adjusted OR: 2.53, 95% CI: 2.41-2.66). Those who reported angina in the 4 wks prior to a protocol visit had 2.2 times greater odds of reporting fair/poor SWB (adjusted OR: 2.2, 95% CI: 2.13-2.27). Female gender, black race, history of smoking, diabetes, myocardial infarction, stroke, and cancer also increased the odds of reporting fair/poor SWB. CONCLUSIONS: Among hypertensive CADpatients, higher on-treatment SBP is associated with greater odds of fair/poor SWB during follow-up.
Authors: Erica M Fallon; Marian Tanofsky-Kraff; Anne-Caroline Norman; Jennifer R McDuffie; Erica D Taylor; Marc L Cohen; Deborah Young-Hyman; Margaret Keil; Ronette L Kolotkin; Jack A Yanovski Journal: J Pediatr Date: 2005-10 Impact factor: 4.406
Authors: Carl J Pepine; Eileen M Handberg; Rhonda M Cooper-DeHoff; Ronald G Marks; Peter Kowey; Franz H Messerli; Giuseppe Mancia; José L Cangiano; David Garcia-Barreto; Matyas Keltai; Serap Erdine; Heather A Bristol; H Robert Kolb; George L Bakris; Jerome D Cohen; William W Parmley Journal: JAMA Date: 2003-12-03 Impact factor: 56.272
Authors: José R Banegas; Esther López-García; Auxiliadora Graciani; Pilar Guallar-Castillón; Juan L Gutierrez-Fisac; Jordi Alonso; Fernando Rodríguez-Artalejo Journal: Eur J Cardiovasc Prev Rehabil Date: 2007-06
Authors: Colleen M Norris; William A Ghali; P Diane Galbraith; Michelle M Graham; Louise A Jensen; Merril L Knudtson Journal: Health Qual Life Outcomes Date: 2004-05-05 Impact factor: 3.186
Authors: David E Winchester; Rhonda M Cooper-Dehoff; Yan Gong; Eileen M Handberg; Carl J Pepine Journal: Clin Cardiol Date: 2013-05-29 Impact factor: 2.882