PURPOSE: To demonstrate the feasibility of acquiring high-resolution, isotropic 3D-sodium magnetic resonance (MR) images of the whole knee joint in vivo at ultrahigh field strength (7.0T) via a 3D-radial acquisition with ultrashort echo times and clinically acceptable acquisition times. MATERIALS AND METHODS: Five healthy controls (four males, one female; mean +/- standard deviation [SD] age 28.7 +/- 4.8 years) and five patients with osteoarthritis (OA) (three males, two females; mean +/- SD age 52.4 +/- 5.6 years) underwent (23)Na MRI on a 7T, multinuclei equipped whole-body scanner. A quadrature (23)Na knee coil and a 3D-gradient echo (GRE) imaging sequence with a radial acquisition were utilized. Cartilage sodium concentration was measured and compared between the healthy controls and OA patients. RESULTS: The average signal-to-noise ratio (SNR) for different spatial resolutions (1.2-4 mm) varied from approximately 14-120, respectively. The mean sodium concentration of healthy subjects ranged from approximately 240 +/- 28 mM/L to 280 +/- 22 mM/L. However, in OA patients the sodium concentrations were reduced significantly by approximately 30%-60%, depending on the degree of cartilage degeneration. CONCLUSION: The preliminary results suggest that sodium imaging at 7T may be a feasible potential alternative for physiologic OA imaging and clinical diagnosis.
PURPOSE: To demonstrate the feasibility of acquiring high-resolution, isotropic 3D-sodium magnetic resonance (MR) images of the whole knee joint in vivo at ultrahigh field strength (7.0T) via a 3D-radial acquisition with ultrashort echo times and clinically acceptable acquisition times. MATERIALS AND METHODS: Five healthy controls (four males, one female; mean +/- standard deviation [SD] age 28.7 +/- 4.8 years) and five patients with osteoarthritis (OA) (three males, two females; mean +/- SD age 52.4 +/- 5.6 years) underwent (23)Na MRI on a 7T, multinuclei equipped whole-body scanner. A quadrature (23)Na knee coil and a 3D-gradient echo (GRE) imaging sequence with a radial acquisition were utilized. Cartilagesodium concentration was measured and compared between the healthy controls and OA patients. RESULTS: The average signal-to-noise ratio (SNR) for different spatial resolutions (1.2-4 mm) varied from approximately 14-120, respectively. The mean sodium concentration of healthy subjects ranged from approximately 240 +/- 28 mM/L to 280 +/- 22 mM/L. However, in OA patients the sodium concentrations were reduced significantly by approximately 30%-60%, depending on the degree of cartilage degeneration. CONCLUSION: The preliminary results suggest that sodium imaging at 7T may be a feasible potential alternative for physiologic OA imaging and clinical diagnosis.
Authors: Sònia Nielles-Vallespin; Marc-André Weber; Michael Bock; André Bongers; Peter Speier; Stephanie E Combs; Johannes Wöhrle; Frank Lehmann-Horn; Marco Essig; Lothar R Schad Journal: Magn Reson Med Date: 2007-01 Impact factor: 4.668
Authors: Gregory Chang; Cem M Deniz; Stephen Honig; Kenneth Egol; Ravinder R Regatte; Yudong Zhu; Daniel K Sodickson; Ryan Brown Journal: J Magn Reson Imaging Date: 2013-09-23 Impact factor: 4.813